Occupational exposure to polycyclic aromatic hydrocarbons: relations between atmospheric mixtures, urinary metabolites and sampling times

International Archives of Occupational and Environmental Health
Damien BarbeauAnne Maitre

Abstract

Occupational exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed by either air monitoring or biomonitoring using urinary 1-hydroxypyrene (1-OHP) or 3-hydroxybenzo(a)pyrene (3-OHBaP). The aim of this study was to understand the links between atmospheric PAHs and urinary metabolites, in order to improve the biomonitoring strategy for assessing carcinogenic risk. Personal air sampling for pyrene and BaP measurements, and urines for 1-OHP and 3-OHBaP analyses of seven workers from electrode production plant were collected every day of the working week. High variability of atmospheric levels between activities and between days was observed, especially for gaseous pyrene. No correlation was found between urinary metabolites: 1-OHP maximum levels occurred for "electrode extrusion" activity; those of 3-OHBaP occurred for "raw materials dispatcher." Sixty percentage of 3-OHBaP maximum levels were observed in urines collected at the beginning of shift the last workday. Those of 1-OHP occurred at different sampling times, depending on the gaseous pyrene levels (not stopped by P3 respirators). Dermal absorption of PAHs was confirmed by significant effect of particulate pyrene on 1-OHP in the samples collected the morning of...Continue Reading

References

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Citations

Dec 15, 2015·Environmental Science and Pollution Research International·Lucia G Pruneda-ÁlvarezIván N Pérez-Maldonado
May 20, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Camille GeniesThierry Douki
Oct 31, 2016·International Journal of Hygiene and Environmental Health·Marta OliveiraSimone Morais
Aug 16, 2016·The Science of the Total Environment·Lucía G Pruneda-AlvarezIván N Pérez-Maldonado
Nov 1, 2016·Environmental Science and Pollution Research International·Ángeles C Ochoa-MartínezIván N Pérez-Maldonado
Nov 6, 2017·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Wei QinJunfeng Dou
Mar 30, 2017·Annals of Work Exposures and Health·Catherine ChampmartinHubert Monnier

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