PMID: 3770957Jan 1, 1986Paper

Occupational fluoride exposure and plasma fluoride levels in man

International Archives of Occupational and Environmental Health
M Ehrnebo, J Ekstrand

Abstract

The individual fluoride exposure and the corresponding body fluid levels were studied in 41 workers in an aluminum plant in Sweden. During the shift (8 h) personal air samplings were performed and plasma fluoride levels determined. Pre- and post-shift urine fluoride excretion were also measured. The average total fluoride exposure was 0.91 mg/m3 of which 34% was gaseous fluoride (mean value 0.31 mg/m3). The mean fluoride plasma level before the shift was 23 ng/ml (1.2 microM/l) and increased on average to 48 ng/ml (range 14-151 ng/ml) at the end of the shift. The plasma levels found were in no case remarkably high. There was a high correlation between fluoride renal clearance and urinary flow (r = 0.481; n = 38; P = 0.00232). A high fluid intake during the shift will thus increase the capacity of the kidney to excrete fluoride and decrease the levels of fluoride in the body. There was a significant correlation between the amount of gaseous fluoride and the area under the plasma concentration-time curve (r = 0.459; n = 40; P = 0.0029) and also the amount of fluoride excreted (r = 0.530; n = 40; P = 0.0004). When fluoride exposure and body burden are to be studied on an individual basis these two parameters give better quantitati...Continue Reading

References

Dec 4, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·C A BaudM A Boillat
Jan 1, 1977·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·H C Hodge, F A Smith
Oct 20, 1977·Calcified Tissue Research·J Ekstrand
Oct 17, 1977·International Archives of Occupational and Environmental Health·A ZoberK H Schaller
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Oct 1, 1983·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·J Ekstrand, M Ehrnebo
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·B VandelD Blum
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·K K Chan, M Gibaldi

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Citations

Jan 1, 1990·International Archives of Occupational and Environmental Health·K KonoK Doi
Mar 25, 2011·Environmental Health and Preventive Medicine·Yu-e SongCai-yan Cui
May 21, 2016·Scandinavian Journal of Gastroenterology·Benoit Follin-Arbelet, Bjørn Moum
Jul 18, 2017·Journal of Environmental and Public Health·Declan T WaughWilliam Potter

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