Occupational infection due to Brucella abortus S19 among workers involved in vaccine production in Argentina

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
J C WallachP C Baldi

Abstract

The pathological consequences of exposure to the vaccine strain Brucella abortus S19 were evaluated in 30 employees from vaccine-manufacturing plants. Active brucellosis was diagnosed in 21 subjects, of whom only five recalled an accidental exposure. Clinical manifestations were mild, and only one patient presented a complication. After antimicrobial therapy, initially symptomatic patients either experienced clinical remission or had mild persistent symptoms. This is the first study reporting infection by B. abortus S19 among workers from vaccine-manufacturing plants, which in many cases was acquired from unnoticed exposures. Measures to improve the safety of B. abortus S19 handling should be implemented.

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Citations

Jul 20, 2011·Infection and Immunity·Beata ClappDavid W Pascual
Nov 17, 2009·Vaccine·Xinghong YangDavid W Pascual
Aug 19, 2014·Preventive Veterinary Medicine·Murat KutluEsra Kazak
Jan 25, 2018·Transboundary and Emerging Diseases·V ProchN K Dhand
May 12, 2020·PLoS Neglected Tropical Diseases·Carine Rodrigues PereiraElaine Maria Seles Dorneles
Dec 19, 2019·Frontiers in Microbiology·Minerva Araiza-VillanuevaAraceli Contreras-Rodríguez
Feb 23, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Claire E WylieNicholas A Buckley
May 11, 2018·PLoS Neglected Tropical Diseases·Balbir B SinghNavneet K Dhand
Jul 12, 2017·Pathogens and Global Health·Rajeswari ShomeHabibur Rahman
Feb 1, 2016·Chemical Science·Mariusz Skwarczynski, Istvan Toth
Jun 17, 2020·Transboundary and Emerging Diseases·Liu BaoshanZeliang Chen
Sep 19, 2019·Vaccine: X·Slim ZribaAngela M Arenas-Gamboa

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