Occupational transmission of hepatitis C in healthcare workers and factors associated with seroconversion: UK surveillance data

Journal of Viral Hepatitis
S E TomkinsF M Ncube

Abstract

The study aims were to describe a case series of occupationally acquired hepatitis C (HCV) infections in UK healthcare workers and examine factors associated with transmission using exposure data reported to the Health Protection Agency between July 1997 and December 2007. Fifteen reported cases of documented HCV seroconversion occurred after percutaneous exposure, the majority from hollow-bore needles used in the source patient's vein or artery and contaminated with blood or blood-stained fluid. The seroconversion rate was 2.2% (14/626). In multivariable analysis of healthcare workers with percutaneous exposure to blood or blood-stained fluid, we demonstrate that blood sampling procedures (odds ratio [OR], 5.75; 95% CI, 1.33-24.91; P = 0.01) and depth of injury (OR for deep vs superficial injury, 21.99; 95% CI, 2.02-239.61; P = 0.02) are independently associated with a greater risk of HCV seroconversion. This is the first UK study of occupationally acquired HCV in healthcare workers. It has reinforced our knowledge of risk factors for HCV transmission. Most of these exposures and transmissions were preventable. Healthcare employers should provide regular education on the risks of occupational exposure and prevention through st...Continue Reading

References

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Citations

Oct 2, 2013·Nature Reviews. Gastroenterology & Hepatology·Mark Thursz, Arnaud Fontanet
Jul 8, 2014·PloS One·Lies BoelenUNKNOWN HITS investigators
Dec 4, 2012·Best Practice & Research. Clinical Gastroenterology·George Papatheodoridis, Angelos Hatzakis
Jul 18, 2014·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Oct 30, 2013·Journal of Medical Virology·David MuirAlison Holmes
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Sep 12, 2015·Archives of Environmental & Occupational Health·Priscilla Santos Ferreira ReamSergiane Bisinoto Alves
Sep 20, 2016·Journal of Hepatology·Håvard MidgardOlav Dalgard
Nov 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susanna NaggieDavid L Thomas
May 4, 2017·Journal of Behavioral Addictions·Andreas ChatzittofisJussi Jokinen
Feb 13, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natasha K MartinMatthew Hickman

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