PMID: 38564May 31, 1979

Occurence and cytodifferentiation of mucopolysaccharide secreting cells in the pancreas of children with nesidioblastosis

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
M C DutrillauxC Rozé


Large numbers of mucopolysaccharide secreting cells were found in the pancreatic tissue of children with nesidioblastosis. Ultrastructural studies showed that mucus cells contained secretion granules and a characteristic smooth endoplasmic reticulum composed of an array of anastomosed tubules. The periodic acid - thiocarbohydrazide - silver reaction demonstrated the presence of glycogen in the hyaloplasm and of polysaccharides in secretion granules, the Golgi apparatus and in vesicles. A hypothesis is proposed, according to which mucus cells differentiate from a pancreatic stem cell common to both endocrine and exocrine tissues, through a mitochondria-rich intermediate cell stage.

Related Concepts

Cell Differentiation Process
Endoplasmic Reticulum
Golgi Apparatus
Islet Cell Adenoma
Electron Microscopy
Malignant Neoplasm of Pancreas

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