Occurrence and distribution of per- and polyfluoroalkyl substances (PFASs) in human livers with liver cancer.

Environmental Research
Ying LiuDa Chen

Abstract

Per- and polyfluoroalkyl substances (PFASs) are anthropogenic compounds that are widely accumulated in human tissues, and the liver is considered a primary target organ for PFASs exposure. The occurrence and distribution of 21 PFASs in liver tissues with tumors (n = 55) and without tumors (n = 55) are investigated in this study. Eleven perfluorinated carboxylic acids (PFCAs) and five perfluorinated sulfonic acids (PFSAs) were detected at high frequencies (45.5%-100 %), while the detection frequencies of five perfluoroalkyl phosphate (PFPAs) were relatively lower (≤29.1 %). PFSAs and PFCAs accounted for up to 82.5%-92.7 % of the total PFASs. Although it was not found to be statistically significant, the concentrations of the total PFASs were slightly higher in the tumor liver samples (mean 64.3, range 5.70-303 ng/g) than those in the non-tumor liver samples (mean 62.7, range 4.08-240 ng/g).The perfluorooctanoic acid (PFOA), perfluorotridecanoic acid (PFTrDA), and perfluorobutanesulphonate (PFBS) showed significant differences (p < 0.05) between the tumor and non-tumor liver samples, and the different distribution levels of these three PFASs may have been a consequence of oxidative stress. The total concentrations of PFASs in the...Continue Reading

References

Jan 1, 1996·Free Radical Biology & Medicine·N De MariaR A Floyd
Jun 24, 1998·Biochemical and Biophysical Research Communications·Y YamamotoT Yoshikawa
Feb 27, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·L B BiegelJ C Cook
May 12, 2001·Environmental Science & Technology·J P Giesy, K Kannan
May 15, 2001·Environmental Science & Technology·K J HansenH O Johnson
Jul 3, 2002·Toxicology·Deanna J LuebkerAndrew M Seacat
Dec 4, 2003·Environmental Health Perspectives·Geary W OlsenLarry R Zobel
Aug 27, 2004·Critical Reviews in Toxicology·Gerald L KennedyDavid G Farrar
Oct 6, 2004·Environmental Science & Technology·Kurunthachalam KannanKenneth M Aldoust
Aug 16, 2005·Chemico-biological Interactions·Jonathan W MartinPeter J O'Brien
Mar 3, 2006·Environmental Science & Technology·Leo W Y YeungPaul K S Lam
May 2, 2006·Environmental Science & Technology·Antonia M CalafatLarry L Needham
Nov 17, 2006·Environmental Health Perspectives·John L ButenhoffAndrea Pfahles-Hutchens
Jun 19, 2008·Environmental Health Perspectives·Theodore A SlotkinFrederic J Seidler
Sep 3, 2008·Environmental Science and Pollution Research International·Ingrid EricsonJosé L Domingo
May 22, 2009·Environmental Science and Pollution Research International·Anna KärrmanGunilla Lindström
Feb 18, 2010·Environmental Science & Technology·Helena NilssonGunilla Lindström
Apr 29, 2010·Environmental Health Perspectives·Kyle SteenlandDavid A Savitz
May 6, 2010·Environmental Science & Technology·Tao ZhangKurunthachalam Kannan
Jun 8, 2011·Environmental Science & Technology·Eva I H LoiNobuyoshi Yamashita
Jul 5, 2011·Chemosphere·Feifei GuoYongning Wu
Aug 23, 2011·Reproductive Toxicology·Maria SundströmJohn L Butenhoff
Aug 26, 2011·Environment International·José L Domingo
Nov 29, 2011·Reproductive Toxicology·James E KlaunigLisa M Kamendulis
Dec 21, 2011·Environmental Health Perspectives·Arnold SchecterLinda Birnbaum
Sep 8, 2012·Analytical and Bioanalytical Chemistry·Shahid UllahUrs Berger
Feb 16, 2013·Journal of Hazardous Materials·H T WanChris K C Wong
Jul 16, 2013·Ecotoxicology and Environmental Safety·Leo W Y YeungChandana B Herath
Jul 31, 2013·Environment International·Francisca PérezMarinella Farré
Aug 29, 2013·Environmental Science & Technology·Yifeng ZhangJonathan W Martin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.