PMID: 6162773Jan 1, 1981Paper

Occurrence and patterns of muramidase containing cells in Hodgkin's disease, non-Hodgkin's lymphomas, and reactive hyperplasia

Human Pathology
H J ReeH Fanger

Abstract

The occurrence and pattern of cytoplasmic muramidase containing histiocytes were studied by the unlabeled antibody peroxidase-antiperoxidase method in biopsy material from patients with Hodgkin's disease, non-Hodgkin's lymphomas, and reactive hyperplasia. The majority of lymph nodes from patients with Hodgkin's disease, nodular lymphoma, and reactive hyperplasia gave positive staining reactions when tested in this manner. Differences in the staining pattern were observed for the different conditions studied. In general, stain positive cells occurred in one of the following four patterns: nodular, dispersed, aggregating without background stain, or aggregating with background stain (mottling pattern). The nodular and aggregating without background stain patterns were not specific and were seen in various conditions. The dispersed pattern, however, was observed only in some cases of non-Hodgkin's diffuse lymphomas, suggesting a subgroup of tumors characterized by active participation of reactive histiocytes. The mottling pattern was virtually limited to Hodgkin's disease. Since the mottling pattern appeared to be produced by virtue of a large amount of extracellular muramidase, the elevation of the serum muramidase level in Hodgk...Continue Reading

Citations

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·J TamaruT Takagi
Oct 15, 1985·Cancer·H J Ree, M E Kadin
May 15, 1987·Cancer·H J ReeC A Dinarello
Jan 1, 1986·Pediatric Pathology·L Penchansky, J R Krause
May 1, 1981·Scandinavian Journal of Haematology·N E Hansen, H Karle
Mar 1, 1983·Journal of Clinical Pathology·R J Sokol, G Hudson
Sep 1, 1981·Scandinavian Journal of Haematology·N E HansenP Christoffersen

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