Occurrence and predictors of metaplastic atrophic gastritis in a nation-wide consecutive endoscopic population presenting with upper gastrointestinal symptoms

European Journal of Gastroenterology & Hepatology
Edith LahnerBruno Annibale

Abstract

The frequency of metaplastic atrophic gastritis in noninvestigated dyspepsia and its associated symptoms pattern are not known. This study aimed to assess the occurrence and clinical predictors of metaplastic atrophic gastritis in a consecutive endoscopic population presenting with upper gastrointestinal symptoms. A post-hoc cross-sectional study was carried out on endoscopic-histological data from 668 patients (64% women, age: 58 years) with upper gastrointestinal symptoms obtained during a multicenter study. Patients with dyspeptic (46%), reflux-like symptoms (22%), and both (32%) as indications for gastroscopy were included. Gastroscopy with biopsies (Sydney System) was performed. Clinical data and symptoms were collected using a structured questionnaire. Metaplastic atrophic gastritis was detected in 201 (30.1%) patients: 22.3% antrum-restricted, 4.5% corpus-restricted, and 3.3% extensive. Postprandial fullness was more frequent in patients with metaplastic atrophic gastritis compared with those without metaplastic atrophic gastritis (29.8 vs. 18.8%, P=0.002); epigastric pain/burning, early satiety, and reflux symptoms occurred similarly in both groups. At multivariate logistic regression, metaplastic atrophic gastritis (an...Continue Reading

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Citations

May 23, 2019·Alimentary Pharmacology & Therapeutics·Marco Vincenzo LentiAntonio Di Sabatino
Jan 18, 2020·Expert Review of Gastroenterology & Hepatology·Bruno AnnibaleEdith Lahner
Sep 6, 2019·Helicobacter·Doron BoltinChristian Schulz
Jul 11, 2020·Nature Reviews. Disease Primers·Marco Vincenzo LentiAntonio Di Sabatino
Jun 17, 2020·Current Gastroenterology Reports·Edith LahnerVito Domenico Corleto
Nov 25, 2020·Microorganisms·Laura ContiEdith Lahner
Dec 10, 2019·Gastroenterology·Osama AltayarReem A Mustafa

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

MedCalc

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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