Occurrence and prevention of contraction bands in Purkinje fibres, transitional cells and working myocardium during global ischaemia

Virchows Archiv. A, Pathological Anatomy and Histopathology
P A SchnabelH J Bretschneider

Abstract

Contraction bands usually occur in the intramural working myocardium following post-ischaemic reperfusion. In the subendocardium, however, they are found during ischaemia. Thus, we ascertained the contraction states of Purkinje fibres, transitional cells, subendocardial and intramural parts of the working myocardium during 30 min global ischaemia at 25 degrees C. The effects with and without myocardial protection were compared. At the onset of pure ischaemia contraction bands are completely lacking in all cell types. During pure ischaemia contraction bands are found in all subendocardial cell types but not in the intramural working myocardium. A peak of pathological contraction states is found in the intramural working myocardium at the onset (0 min), in the subendocardial working myocardium at 10 min, in the transitional cells and Purkinje fibres at 30 min of pure ischaemia. Histidine-, tryptophan-, ketoglutarate-enriched (HTK) cardioplegia prevents contraction bands completely at the onset of ischaemia and prevents both contraction bands and pathological contraction states during ischaemia almost completely. Striking differences in the physiological contraction states are seen only in the working myocardium: HTK cardioplegia ...Continue Reading

References

Dec 1, 1979·AJR. American Journal of Roentgenology·E R Weibel
Sep 1, 1976·Journal of Molecular and Cellular Cardiology·L E ThornellK E Andersson
Jan 1, 1986·Human Pathology·S B Karch, M E Billingham
Dec 1, 1986·Journal of Molecular and Cellular Cardiology·M M AdamantidisB A Dupuis
Jun 1, 1987·The Thoracic and Cardiovascular Surgeon·P A SchnabelH J Bretschneider
Jul 1, 1989·Basic Research in Cardiology·M Ashraf, P M Rahamathulla
May 1, 1988·Progress in Cardiovascular Diseases·D J Hearse
Feb 1, 1987·Circulation Research·D G Allen, C H Orchard
Nov 1, 1987·The American Journal of Physiology·S M Poler, L Reuss
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M A VanderweeL C Armiger
Mar 1, 1982·Basic Research in Cardiology·N S DhallaR E Beamish
Feb 1, 1984·The American Journal of Cardiology·H J Marriott
Feb 1, 1983·Journal of Molecular and Cellular Cardiology·C E Ganote
Jan 1, 1983·Advances in Experimental Medicine and Biology·P K SingalN S Dhalla
Jan 1, 1983·Cell and Tissue Research·E CanaleJ J Smolich
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·C L BerryR Wyse

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