PMID: 3214183Dec 1, 1988Paper

Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase

Archives of Biochemistry and Biophysics
M NishikimiK Yagi

Abstract

Humans, other primates, and guinea pigs are missing an enzyme L-gulono-gamma-lactone oxidase which catalyzes the last step of L-ascorbic acid biosynthesis. We have recently isolated a cDNA encoding this enzyme of the rat (T. Koshizaka, M. Nishikimi, T. Ozawa, and K. Yagi (1988) J. Biol. Chem. 263, 1619-1621). Northern blot hybridization using this cDNA as a probe demonstrated that guinea pigs lack mRNA for L-gulono-gamma-lactone oxidase. Nevertheless, existence of a DNA sequence related to this enzyme in the genome of this animal was shown by Southern blot hybridization. The human genome was also found to contain a sequence that is hybridizable with the cDNA probe; however, the degree of hybridization was less than those of hybridization with the L-gulono-gamma-lactone oxidase genes of animals possessing the enzyme, suggesting that the human L-gulono-gamma-lactone oxidase gene has diverged more rapidly than the genes of L-ascorbic acid-synthesizing species. This hypothesis was confirmed by comparison of a partial nucleotide sequence of the human gene with that of the rat one. The L-gulono-gamma-lactone oxidase-related sequences in the guinea pig and human genomes may represent the remnants of the gene of the enzyme that were on...Continue Reading

References

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Citations

May 5, 2001·Annual Review of Plant Physiology and Plant Molecular Biology·Nicholas SmirnoffFrank A Loewus
Mar 27, 2012·Journal of Clinical Biochemistry and Nutrition·Takafumi SenmaruGoji Hasegawa
Apr 14, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Martin Schencking, Karin Kraft
Jan 31, 2014·Journal of Nutritional Science and Vitaminology·Akiko AmanoAkihito Ishigami
Jan 20, 2016·Antioxidants·Celia Chávez-MendozaMaria Antonia Flores-Cordova
Dec 24, 2015·Plant Physiology and Biochemistry : PPB·Siddique I Aboobucker, Argelia Lorence
Mar 17, 2009·BMC Systems Biology·Seongwon Seo, Harris A Lewin
Dec 12, 2012·Biochemical and Biophysical Research Communications·Yuki KishimotoAkihito Ishigami
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Jan 9, 2019·Frontiers in Plant Science·Simon StrobbeDominique Van Der Straeten
Nov 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natalia Smith-CortinezKlaas Nico Faber
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Feb 23, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Seong-Hoon ParkSae-Ron Shin
Mar 25, 2005·Journal of Cell Science·Elizabeth G Canty, Karl E Kadler

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