PMID: 2112367Jun 1, 1990Paper

Occurrence of 9- and 13-keto-octadecadienoic acid in biological membranes oxygenated by the reticulocyte lipoxygenase

Archives of Biochemistry and Biophysics
H KühnL Alder

Abstract

Membranes of intact rabbit reticulocytes and rat liver mitochondrial membranes oxygenated by the pure reticulocyte lipoxygenase contain 13-keto-9Z,11E-octadecadienoic acid and 9-keto-10E,12Z-octadecadienoic acid. In mitochondrial membranes not treated with lipoxygenase and in rabbit erythrocyte membranes these products were not detected. The chemical structure of the compounds has been identified by cochromatography with authentic standards on various types of HPLC columns, by uv and ir spectroscopy and GC/MS. In the membranes of rabbit reticulocytes up to 2% of the linoleate residues are present as its 9- and 13-keto derivatives. Most of the keto compounds (up to 90%) are esterified in the membrane ester lipids, only about 10% were found in the free fatty acid fraction. It is proposed that the keto dienoic fatty acids are formed via decomposition of hydroperoxy polyenoic fatty acids originating from the oxygenation of the membrane lipids by the reticulocyte lipoxygenase.

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Citations

Jan 1, 1996·Free Radical Biology & Medicine·K SchnurrT Schewe
Apr 27, 2001·Mechanisms of Ageing and Development·G Spiteller
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Hartmut KuhnRalf Jürgen Kuban
Mar 1, 1991·Photochemistry and Photobiology·A L Nascimento, G Cilento
Jul 3, 2013·Molecular Nutrition & Food Research·Michel LagardeMichel Guichardant
Dec 2, 2014·Progress in Lipid Research·Thomas HornDagmar Heydeck
Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mauro MaccarroneMassimo Taccone-Gallucci
Nov 27, 2009·European Journal of Medicinal Chemistry·Dimitra Hadjipavlou-LitinaDionissios Papaioannou
Oct 2, 2002·Journal of Neurochemistry·Mauro MaccarroneAlessandro Finazzi-Agrò
Mar 10, 2017·IUBMB Life·Sebastian Doll, Marcus Conrad
Jul 7, 2020·The FEBS Journal·Florian ReischHartmut Kuhn
Sep 13, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marlena RademacherAstrid Borchert

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