PMID: 7539508Jul 1, 1995Paper

Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (gp70) hypervariable region 1 in viremic hepatitis C virus-infected patients

Journal of Virology
E ScarselliC Traboni

Abstract

The hepatitis C virus (HCV) is a frequent cause of chronic liver disease. A mechanism proposed as being responsible for virus persistence is evasion of the host immune response through a high mutation rate in crucial regions of the viral genome. We have sequenced the hypervariable region 1 (HVR1) of the virus isolated from three serum samples, collected during 18 months of follow-up, from an asymptomatic HCV-infected patient. A synthetic peptide of 27 amino acids, corresponding to the HVR1 sequence found to be predominant in both the second and third samples, was used as the antigen for detection of antibodies by enzyme-linked immunosorbent assay (ELISA). We observed reactivity against this HVR1 sequence in the first serum sample before the appearance of the viral isolate in the bloodstream; the reactivity increased in the second and third samples while the cognate viral sequence became predominant. Moreover, our results show that antibodies from all three samples recognize a region mapping at the carboxyl-terminal part of the HVR1 and are cross-reactive with the HVR1 sequence previously found in the same patient. The presence of anti-HVR1 antibodies was investigated in a further 142 HCV patients: 121 viremic and 21 nonviremic....Continue Reading

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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·C M Walker
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A CerinoM U Mondelli
Apr 30, 2003·World Journal of Gastroenterology : WJG·Xin-Xin ZhangYuan Wang
Jun 12, 2003·World Journal of Gastroenterology : WJG·Bing-Shui XiuCui-Xia Zhu
Mar 3, 2006·Immunology and Cell Biology·Lisa N ElliotRosemary A Ffrench
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tomasz LaskusAndrea Kovacs
Jan 1, 1997·Springer Seminars in Immunopathology·P FarciR H Purcell
Apr 12, 2000·Journal of Viral Hepatitis·D B Smith
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joseph TorresiDavid C Jackson
Feb 23, 2012·Scientific Reports·David S CampoYury Khudyakov
Oct 3, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Justyna KaźmierczakMarek Radkowski
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pavel SkumsYury Khudyakov
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HattoriS Kakumu
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·P FarciR H Purcell
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M U MondelliE Silini
Dec 19, 2002·The International Journal of Artificial Organs·F FabriziP Martin

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