Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps

American Journal of Respiratory and Critical Care Medicine
L UllerJonas S Erjefalt

Abstract

The paradigm states that inflammatory cells disappear from airway tissues through apoptosis and phagocytosis. However, cells may also be cleared through primary cytolysis, necrosis secondary to apoptosis, or transepithelial migration. This study examines the occurrence of apoptosis, secondary necrosis, and cytolysis of eosinophils in human nasal polyps in vivo and blood eosinophils in vitro. Eosinophils abounded in subepithelium and in paracellular epithelial pathways. Macrophages commonly occurred but without engulfed eosinophils. Scattered cells, including epithelial cells, were stained by antibody to the caspase cleavage product of poly(ADP-ribose) polymerase. Few cells were apoptotic (stained by terminal deoxy RNase nick end labeling). Of more than 3,000 examined tissue eosinophils, 110 were caspase cleavage positive, but only one was apoptotic. Transmission electron microscopy analysis of more than 500 eosinophils revealed viable and cytolytic eosinophils but not apoptosis, secondary necrosis, or engulfment of eosinophils. Plasma cells but neither epithelial cells nor eosinophils exhibited apoptotic ultrastructural morphology. Eosinophils in vitro exhibited different stages of apoptosis, ending with secondary necrosis dist...Continue Reading

References

Dec 15, 1991·Journal of Immunological Methods·T T HanselC Walker
Aug 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H KreipeM R Parwaresch
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·K L WoolleyP M O'Byrne
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R P Schleimer, B S Bochner
Mar 1, 1996·International Archives of Allergy and Immunology·L B MartinG J Gleich
Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·K L WoolleyM J Woolley
Mar 1, 1996·Acta Oto-laryngologica·R Jankowski
Aug 1, 1996·European Journal of Immunology·H HebestreitH U Simon
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·T AdachiS Makino
May 29, 1998·The New England Journal of Medicine·M E Rothenberg
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·J S ErjefältG A Persson
Nov 7, 1998·American Journal of Respiratory Cell and Molecular Biology·A DruilheM Pretolani
Feb 11, 1999·The New England Journal of Medicine·A M Dvorak
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·J S ErjefältC G Persson
Jul 10, 1999·The Journal of Allergy and Clinical Immunology·K Ohta, N Yamashita
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·C Haslett
Dec 22, 1999·Trends in Pharmacological Sciences·C WardA G Rossi
Jan 26, 2000·The Laryngoscope·A DavidssonH B Hellquist
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·J S Erjefält, C G Persson
Aug 6, 2000·Cell and Tissue Research·C Stadelmann, H Lassmann
Sep 13, 2000·The Journal of Allergy and Clinical Immunology·G K FanH Takenaka
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·J H ParkD K Milton
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·P M HensonV A Fadok
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·L UllerJ S Erjefält
Aug 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Fabio BucchieriDonna E Davies
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shyra J GardaiDonna L Bratton
Jun 25, 2003·American Journal of Respiratory Cell and Molecular Biology·Mary P O'SullivanMichael J Holtzman
Oct 1, 2003·The European Respiratory Journal·C J A DuncanG M Walsh
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Bruce S Bochner

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Citations

Oct 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·Chang-Qing ZhaoLi-Yang Dai
Nov 26, 2013·Nature Reviews. Immunology·Carl Persson, Lena Uller
May 24, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Ron Eliashar, Francesca Levi-Schaffer
Nov 21, 2009·American Journal of Respiratory and Critical Care Medicine·Cecilia K AnderssonJonas S Erjefält
Mar 26, 2005·American Journal of Respiratory and Critical Care Medicine·Leonardo FabbriEdward Abraham
May 13, 2010·Respiratory Research·Lena UllerCarl G Persson
Jun 15, 2010·Respiratory Research·Carl G Persson, Lena Uller
Dec 15, 2006·Respiratory Research·Kristina Rydell-TörmänenJonas S Erjefält
Jul 7, 2009·Future Virology·Bernhard DietzscholdMatthias Schnell
Dec 18, 2013·American Journal of Respiratory and Critical Care Medicine·Carl Persson
Feb 12, 2014·American Journal of Respiratory and Critical Care Medicine·Carl Persson, Lena Uller
Dec 17, 2008·Pulmonary Pharmacology & Therapeutics·Pinja IlmarinenHannu Kankaanranta
Oct 28, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Edith Bielek
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Jan 6, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L UllerJ S Erjefält
Aug 21, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Persson
Nov 8, 2011·British Journal of Pharmacology·Carl Persson, Lena Uller
Apr 15, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H F Rosenberg
Dec 18, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Persson
Aug 1, 2006·Trends in Pharmacological Sciences·Lena UllerJonas S Erjefält
May 26, 2015·The Journal of Surgical Research·Yan ZhangJin Zhang
Sep 12, 2017·Nature Reviews. Immunology·Peter F Weller, Lisa A Spencer
Feb 20, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiang ZhuNives Zimmermann
Nov 22, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephane EsnaultNizar N Jarjour
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neda FarahiEdwin R Chilvers
Apr 30, 2017·Current Allergy and Asthma Reports·Shigeharu UekiMakoto Hirokawa
Oct 12, 2019·The European Respiratory Journal·Pieter S Hiemstra, Peter J Sterk
Jun 17, 2019·Current Allergy and Asthma Reports·Shigeharu UekiPeter F Weller
Oct 8, 2009·American Journal of Rhinology & Allergy·Miguel ArmengotCarmen Carda
Dec 2, 2019·International Archives of Allergy and Immunology·Hans-Uwe SimonHelene F Rosenberg

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