PMID: 21739042Jul 9, 2011Paper

Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii

Memórias do Instituto Oswaldo Cruz
Karyne Rangel CarvalhoMarise Dutra Asensi

Abstract

The aim of the current study was to describe the occurrence of the blaOXA-23 gene and the ISAba1 element in imipenem-susceptible Acinetobacter baumannii strains. By performing the polymerase chain reaction mapping using combinations of ISAba1 forward primers and the blaOXA-23-like gene reverse primers, we demonstrated that the ISAba1 element did not occur upstream of the blaOXA-23 gene in five of 31 isolates, which explained the lack of resistance to imipenem despite the presence of the blaOXA-23 gene. All of the blaOXA-23-positive isolates were susceptible to imipenem and meropenem with minimal inhibitory concentration ≤ 4 µg/mL. Pulsed-field gel electrophoresis analysis revealed four genotypes among the five blaOXA-23-positive isolates. The current report of the blaOXA-23 gene in imipenem-susceptible isolates provided evidence that this gene may be silently spread in a hospital environment and highlighted the threat of undetected reservoirs of carbapenemase genes.

References

Apr 25, 2006·FEMS Microbiology Letters·Jane F TurtonTyrone L Pitt
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Stéphane CorvecPatrice Nordmann
Jan 16, 2008·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Feb 14, 2009·International Journal of Antimicrobial Agents·Karyne Rangel CarvalhoMarise Dutra Asensi
Sep 18, 2009·Journal of Infection in Developing Countries·Raffaele ZarrilliAthanassios Tsakris
Sep 23, 2009·Antimicrobial Agents and Chemotherapy·Paul G HigginsHarald Seifert
Dec 25, 2009·Emerging Infectious Diseases·Pauline D MugnierPatrice Nordmann

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Citations

Jul 28, 2013·SpringerPlus·Marketa SenkyrikovaMilan Kolar
Dec 3, 2014·Comparative Immunology, Microbiology and Infectious Diseases·Chih-Ming ChenChao-Chin Chang
Oct 3, 2013·Journal of Medical Microbiology·Badrul HasanRabaab Zahra
Dec 6, 2016·Expert Review of Anti-infective Therapy·Kevin Escandón-VargasMaría Virginia Villegas
Sep 7, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Vanessa Cristine KobsPaulo Henrique Condeixa de França
Sep 12, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Elaini Aparecida de OliveiraCláudia Rezende Vieira de Mendonça-Souza
Mar 28, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Patrik MlynarcikMilan Kolar
Mar 18, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Gabrielle Limeira GenteluciMaria Helena Simões Villas Bôas

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