Occurrence of Enterococcus faecalis and Enterococcus faecium in Various Clinical Infections: Detection of Their Drug Resistance and Virulence Determinants

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Ali JahansepasJalal Mardaneh

Abstract

The aim of this study was to characterize virulence determinants and antibiotic resistance profiles in enterococci obtained from various clinical sources in the northwest of Iran. A total of 160 enterococcal clinical isolates from various wards of University Teaching Hospitals were collected and specified by biochemical test, from September 2014 to July 2015. Identification of enterococci was confirmed by multiplex PCR in the genus and species level. Antibiotic resistance properties and virulence determinants were examined by phenotypic and molecular methods. Of 160 enterococcal isolates, 125 (78.12%) and 35 (21.88%) isolates were identified as Enterococcus faecalis and Enterococcus faecium, respectively. The most common antibiotic nonsusceptible pattern observed was resistance toward rifampicin [n = 122 (76.25%)] followed by erythromycin [n = 117 (73.12%)]. Among all isolates, gelE [n = 140 (87.5%)], cpd [n = 137 (85.6%)], and asa1 [n = 118 (73.8%)] were the most prevalent virulence genes studied. Thirty isolates (11 E. faecalis, 19 E. faecium) were found to be resistant to vancomycin, with minimum inhibitory concentration of ≥256 μg/ml. Twenty-seven isolates carried the vanA gene, whereas none of the isolates carried vanB. E....Continue Reading

References

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Citations

Oct 24, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mohamed O Ahmed, Keith E Baptiste
Feb 28, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Basant Elmetwally AladaroseEman Salama Abdelmegeed
Aug 30, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Reza BeigverdiMohammad Emaneini
Dec 2, 2018·Infectious Disorders Drug Targets·Mahmoud KhodabandehRamazan Rajabnia
Nov 21, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Thomas K MaatmanMichael G House
May 10, 2020·BioMed Research International·Wafa F S BadullaMohamed Izham Mohamed Ibrahim
Aug 24, 2021·Interdisciplinary Perspectives on Infectious Diseases·Sepide NamdariAfsaneh Moaddeb

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS22

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