PMID: 11906916Mar 22, 2002Paper

Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition

Biology of Reproduction
G SchulerBernd Hoffmann

Abstract

The bovine placenta produces estrogens from the first trimester until the end of its life span. However, with the exception of the immediate prepartal and intrapartal phases, in which an involvement of placental estrogens has been suggested for the preparation of parturition, their function has not been elucidated yet. To test for a role of placental estrogens as local factors regulating placental growth and differentiation, placentomes from cows that were pregnant for 150, 220, 240, and 270 days, and parturient cows (3 animals per group) were screened immunohistochemically for the expression of estrogen receptor alpha (ERalpha). Indirect immunoperoxidase staining methods were applied using primary monoclonal antibodies (pmAbs) directed against the C-terminus (AER311, HT277) or the N-terminus (AER314, 1D5) of the ERalpha molecule. Both types of pmAbs identified ERalpha in stromal cells and capillary pericytes of the maternal caruncular septae. Using pmAb 1D5, the mean percentage of ERalpha-positive caruncular stromal cells decreased from 39.0% +/- 5.9% in pregnant cows to 17.5% +/- 8.3% at parturition (P = 0.011). Only pmAb recognizing the C-terminus identified ERalpha in the caruncular epithelium, in which positive reactions w...Continue Reading

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Citations

Mar 30, 2006·Reproductive Biology and Endocrinology : RB&E·Maie D Al-Bader
Oct 28, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Dominik StreylStefan Bauersachs
Jan 6, 2010·International Journal of Endocrinology·Yonatan FeuermannAvi Shamay
Jun 10, 2005·Reproduction in Domestic Animals = Zuchthygiene·H M MutembeiB Hoffmann
Jan 12, 2007·Reproduction in Domestic Animals = Zuchthygiene·C KohlerB Hoffmann
Nov 11, 2008·Reproduction in Domestic Animals = Zuchthygiene·M M M Abd-ElnaeimG Schuler
Mar 21, 2012·Molecular Reproduction and Development·Phuong T T NguyenRita S F Lee
Mar 13, 2016·Molecular Reproduction and Development·Nitin M AttupuramH Kumar
Mar 26, 2021·Domestic Animal Endocrinology·G Schuler
Jun 28, 2011·Theriogenology·H R Kohan-GhadrR C Lefebvre

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