Occurrence of exocrine pancreatic insufficiency in patients with advanced neuroendocrine tumors treated with somatostatin analogs.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Maria RinzivilloFrancesco Panzuto

Abstract

Although exocrine pancreatic insufficiency (EPI) has been described in patients with neuroendocrine neoplasia (NEN) treated with somatostatin analogs (SSAs), its role in the therapeutic management of these patients is not well established. To determine the frequency of EPI in patients with NEN long-term treated with SSAs. This is a prospective single-center study evaluating 35 patients treated with SSAs for >12 months due to unresectable/advanced nonpancreatic well-differentiated NEN. Clinical evaluation, biochemical parameters, and fecal elastases 1 (FE-1) were assessed to diagnose EPI. A total of 7 patients (20%) had EPI, given the presence of abdominal symptoms and a median FE-1 value of 180 mcg/g stool (150-198). No patient had severe EPI, defined as FE-1 < 100 mcg/g stool. Elevated glycated Hb levels were a significant predictor for developing EPI (OR 4.81, p = 0.01). No significant difference in terms of duration of SSA treatment was observed between patients with or without EPI diagnosed (84 months and 72 months, respectively; p = 0.950). Mild-moderate EPI is a relatively common condition in patients receiving long-term treatment with SSAs. Specific clinical and biochemical evaluations, including FE-1, should be planned ...Continue Reading

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Citations

Aug 6, 2020·Journal of Clinical Medicine·Sara PuscedduFilippo de Braud
Dec 19, 2020·Expert Opinion on Drug Safety·Apostolos Koffas, Christos Toumpanakis
Feb 4, 2021·Expert Opinion on Drug Safety·Francesco PanzutoMaria Rinzivillo
Jan 16, 2021·Journal of Clinical Medicine·Francesco Panzuto
Apr 9, 2021·Expert Opinion on Drug Safety·Francesco PanzutoMaria Rinzivillo
Apr 20, 2021·Expert Opinion on Drug Safety·Lewis HallKeith Roberts

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