Occurrence of hydrin 2 (vasotocinyl-Gly), a new hydroosmotic neurohypophyseal peptide, in secretory granules isolated from the frog (Rana esculenta) neurointermediate pituitary

Neuroendocrinology
J ChauvetR Acher

Abstract

Neurohypophyseal secretory granules have been purified from the frog (Rana esculenta) neurointermediate pituitary gland by sucrose gradient centrifugation, and their polypeptide content has been analyzed by reverse-phase high-pressure liquid chromatography. Aside from vasotocin, mesotocin, and their associated neurophysins, hydrin 2 (vasotocinyl-Gly), previously identified in hydrochloric acid extracts, has been recognized. This finding supports the previous suggestion that hydrin 2, a peptide active on the water permeability of frog bladder and frog skin, is a secreted hormone involved in osmoregulation specific to amphibians. Hydrin 2 has not been found in neurosecretory granules of birds such as the goose.

Citations

Sep 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·P F SilveiraZ P Picarelli
Apr 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·C B Jorgensen
Oct 1, 1993·Progress in Neurobiology·L H Lazarus, M Attila
Apr 16, 1998·Regulatory Peptides·C H Hoyle

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