PMID: 9173203Mar 15, 1997Paper

Occurrence of immune hyperthyroidism after radioiodine therapy of autonomous goiter

Medizinische Klinik
C HirschM Schwaiger

Abstract

The goal of the study was to examine the prevalence of Graves' disease following I-131 treatment of autonomous goiter with special regard to pretreatment scintigraphic patterns. Pre- and posttreatment in-vitro and in-vivo parameters were studied in 375 consecutive patients treated with I-131 therapy for nodular or diffuse autonomous goiter. All patients included were within ambulant control for at least 2.5 months following treatment. According to the pretreatment Tc-99m pertechnetate scan 59% (220/375) had multifocal (MF), 23% (86/375) unifocal (UF), 10% (38/375) mixed focal-disseminated (FD) and 8% (31/375) disseminated (D) scintigraphic patterns. In 93.9% (352/375), the autonomous tissue was totally, in 2.1% (8/375) partially and in 1.6% (6/375) insufficiently eliminated. In 2.4% (9/375) a relapse of hyperthyroidism was observed 2 to 10 months following I-131 therapy. In 8 patients a relapse of hyperthyroidism was accompanied or followed by an elevation of the previously non-elevated TSH-receptor antibody (TRAb) level and in 1 patient by an TRAb increase to the upper borderline range implicating Graves' disease. With the prevalence of Graves' disease following I-131 therapy a statistically significant difference in pretreatm...Continue Reading

References

Jan 1, 1992·Experimental and Clinical Endocrinology·M LudgateG Vassart
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·Z KraiemM Sheinfeld
Jan 1, 1987·Acta Endocrinologica. Supplementum·C SellschoppH Hamelmann
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R D WasnichJ P Kriss
Oct 2, 1993·BMJ : British Medical Journal·B NygaardJ M Hansen

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