Occurrence of Pineal Gland Tumors in Combined Chronic Toxicity/Carcinogenicity Studies in Wistar Rats

Toxicologic Pathology
Silke TreumannBennard van Ravenzwaay

Abstract

Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and unrelated to treatment. The morphology and immunohistochemical evaluation led to the diagnosis malignant pinealoma. The main characteristics that were variably developed within the tumors were the following: cellular atypia, high mitotic index, giant cells, necrosis, Homer Wright rosettes, Flexner-Wintersteiner rosettes and pseudorosettes, positive immunohistochemical reaction for synaptophysin, and neuron-specific enolase. The pineal gland is not a protocol organ for histopathological examination in carcinogenicity studies. Nevertheless, the pineal gland can occasionally be encountered on the routine brain section or if it is the origin of a tumor protruding into the brain, the finding will be recorded. Therefore, although known to be a rare tumor in rats, pineal neoplasms should be included in the list of possible differential diagnoses for brain tumors, especially when the tumor is located in the region of the p...Continue Reading

References

Apr 1, 1985·Journal of Comparative Pathology·G KrinkeK Schnider
Feb 11, 2000·Toxicologic Pathology·G J KrinkeP Schaetti
Nov 18, 2004·Regulatory Toxicology and Pharmacology : RTP·Henk TennekesBennard van Ravenzwaay
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Mar 31, 2009·Progress in Neurological Surgery·Kazufumi Sato, Toshihiko Kubota
Jan 5, 2011·Toxicologic Pathology·Klaus WeberIngrid D Pardo
Jan 30, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Bennard van RavenzwaayHenk Vrijhof
Mar 29, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Jos Kleinjans, Bennard van Ravenzwaay

❮ Previous
Next ❯

Citations

Mar 29, 2020·Nanotoxicology·Jutta TentschertAndreas Luch
Aug 31, 2018·Journal of Toxicologic Pathology·Annamaria Brändli-BaioccoThomas J Rosol
Jan 27, 2021·Journal of Comparative Pathology·Chiaki MizukamiManabu Yamada

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
environmental stress

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Rassegna internazionale di clinica e terapia
B BUONOMO LA ROSSA
Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians
Elizabeth C DobsonDenise McAloose
© 2022 Meta ULC. All rights reserved