PMID: 13575670Sep 1, 1958Paper

Occurrence of R antigen specific for Group A type 3 streptococci

The Journal of Experimental Medicine
R C LANCEFIELD

Abstract

Approximately 50 per cent of Group A, Type 3 streptococci contain a hitherto undescribed antigen found only in Group A, Type 3 organisms. It is serologically distinct from Type 3 M antigen and is designated as 3 R antigen. Strains containing 3 R antigen but no Type 3 M antigen are "glossy," avirulent Type 3 variants. These strains can be obtained by repeated transfers of virulent M-containing streptococci in artificial media under unfavorable conditions of growth. These degraded streptococci recover Type 3 M antigen during serial passage through mice. The amount of 3 R antigen in a strain is not affected by a decrease or increase in M antigen. The 3 R antigen is unrelated to virulence. Antibodies to this antigen do not protect mice against infection or promote phagocytosis in bactericidal tests. The 3 R antigen-antibody system can give rise to confusion in M-precipitin reactions. In all these properties 3 R antigen is similar to 28 R antigen, although in certain other properties the two R antigens are not identical. They are serologically distinct. Virulence and ability to grow in normal human blood under the conditions of the bactericidal test are correlated with the presence of M antigen of Group A, Type 3 streptococci. Mouse...Continue Reading

References

Apr 1, 1953·The Journal of Pathology and Bacteriology·W R MAXTED
Feb 1, 1958·Journal of General Microbiology·J S HAMBLY
Jul 1, 1952·The Journal of Experimental Medicine·R C LANCEFIELD, G E PERLMANN

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Citations

Nov 1, 1965·The Journal of Pediatrics·W F Friedman
Aug 1, 1959·The Journal of Experimental Medicine·R C LANCEFIELD
Sep 1, 1959·The Journal of Experimental Medicine·Z A COHN, S I MORSE
Oct 1, 1967·The Journal of Experimental Medicine·F H TopB F Anthony
Nov 1, 1971·The Journal of Experimental Medicine·J RottaH Lackland
Nov 1, 1984·The Journal of Experimental Medicine·G J Russell-Jones, E C Gotschlich
Jan 1, 1978·Microbiology and Immunology·S MaekawaY Nakayama
May 16, 2002·Infection and Immunity·Tadayoshi IkebeUNKNOWN Working Group for Group A Streptococcus in Japan
Nov 19, 2013·Trends in Microbiology·Kristofer Wollein Waldetoft, Lars Råberg
Apr 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·V LindénP Christensen
Oct 1, 1972·Applied Microbiology·H W Wilkinson
Jul 1, 1971·Infection and Immunity·W K HarrellR E Davis
Nov 1, 1971·Infection and Immunity·H W Wilkinson, R G Eagon
May 1, 1989·Journal of Clinical Microbiology·A E Flores, P Ferrieri
Oct 1, 1996·Journal of Clinical Microbiology·A L BisnoJ C Turner

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