PMID: 8588336Nov 1, 1995Paper

Occurrence of T lymphocytes in perivascular regions of the lung after intratracheal infection of swine with Pasteurella multocida

Veterinary Immunology and Immunopathology
A Berndt, G Müller

Abstract

The defence mechanisms of the lung acting against airborne antigens (bacteria) are not yet fully understood. Therefore, we investigated cell-derived immunological processes in porcine pulmonary tissue. The incidence and distribution of leukocyte subpopulations in lungs, lung lymph nodes and tonsils from eight animals intratracheally infected with Pasteurella multocida (P.m.) type A wild strain and from four non-infected control animals were established by immunohistochemistry, using a panel of monoclonal antibodies (mAbs) against specific porcine leukocyte antigens: MHC Class II (MHC II), SWC1, SWC3a, CD2a, CD4a, CD8b. In the test animals, a broad layer of SWC1+ cells and SWC3a+ cells emerged in the subsinusoidal region of lung lymph nodes and in the bronchoalveolar spaces of the lung as early as 4 and 24 h after infection, and in the subsinusoidal regions of the lung lymph nodes only very few cells could be stained with the mAb against the MHC II antigen. We could not detect any MHC Class II+ cells in the bronchoalveolar spaces at this time of the investigation. In the course of the disappearance of the SWC1+ cells and SWC3+ cells, CD2a+, CD4a+ and, in lower numbers, CD8b+ T lymphocytes seemed to concentrate in the perivascula...Continue Reading

References

Nov 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L A Sternberger, S A Joseph
Nov 1, 1989·European Journal of Immunology·A SaalmüllerM J Reddehase
Sep 1, 1987·European Journal of Immunology·A SaalmüllerU H Koszinowski
May 1, 1988·The Journal of Allergy and Clinical Immunology·B UpadrashtaH B Richerson
Feb 1, 1986·Veterinary Immunology and Immunopathology·C Hammerberg, G G Schurig
Oct 1, 1994·Veterinary Immunology and Immunopathology·A SaalmüllerH Salmon
Oct 1, 1994·Veterinary Immunology and Immunopathology·R Pabst, R M Binns
Apr 1, 1993·Immunology Today·J K Lunney

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Citations

Jul 1, 1997·Veterinary Immunology and Immunopathology·A Berndt, G Müller
May 21, 2013·The Veterinary Journal·Susanne E PorsTine M Iburg
May 15, 2021·Frontiers in Medicine·Eric DenesChristian Martin

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