Occurrence of trans fatty acids in rats fed a trans-free diet: a free radical-mediated formation?

Free Radical Biology & Medicine
Laura ZamboninLaura Landi

Abstract

Trans isomers of unsaturated fatty acids are absorbed from the diet, due to their presence in diary fat and hydrogenated vegetable oils, and health concern has risen due to their effects on lipid risk factors in cardiovascular diseases. On the basis of the efficiency of the thiyl-radical-catalyzed cis/trans isomerization in vitro and the presence of many sulfur-containing compounds in the cell, the aim of this study was to demonstrate that trans geometry of lipid double bonds can be endogenously generated within membrane phospholipids. The study reports trans fatty acids occurrence in tissue and erythrocyte phospholipids of young adult rats fed a diet completely free of trans isomers. Results show that tissues are differently prone to the endogenous isomerization and that, following a free radical attack, trans fatty acids can reach very high amounts. The effectiveness of this process is considerably inhibited in the presence of all-trans retinol, confirming previous data in model membranes. Our results suggest that geometrical isomerization of unsaturated fatty acids, which causes a structural modification of membrane lipids and may influence basic membrane properties and vital biochemical functions, can occur under radical st...Continue Reading

References

Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Jul 18, 2001·Journal of the American Chemical Society·C FerreriC Chatgilialoglu
Feb 5, 2003·The American Journal of Medicine·Alberto Ascherio
Dec 18, 2003·Annals of Nutrition & Metabolism·Steen Stender, Jørn Dyerberg
Nov 9, 2004·Chembiochem : a European Journal of Chemical Biology·Carla FerreriChryssostomos Chatgilialoglu
Mar 9, 2005·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Chryssostomos ChatgilialogluHanns Fischer
Apr 6, 2005·Free Radical Biology & Medicine·Carla FerreriChryssostomos Chatgilialoglu
May 4, 2005·Cellular and Molecular Life Sciences : CMLS·C FerreriO Brede

❮ Previous
Next ❯

Citations

Oct 5, 2007·Molecular Biotechnology·Carla FerreriChryssostomos Chatgilialoglu
Jan 31, 2012·Chemical Research in Toxicology·Carla FerreriChryssostomos Chatgilialoglu
Oct 25, 2011·Lipids in Health and Disease·Marina MariniCarla Ferreri
Nov 17, 2012·Expert Review of Molecular Diagnostics·Carla Ferreri, Chryssostomos Chatgilialoglu
Sep 21, 2013·Chemical Reviews·Chryssostomos ChatgilialogluArmida Torreggiani
Sep 16, 2009·Free Radical Biology & Medicine·Jane A Leopold, Joseph Loscalzo
Sep 11, 2008·Bioorganic & Medicinal Chemistry·Carla FerreriAthanassia Siafaka-Kapadai
Jul 9, 2008·Pharmacology & Therapeutics·Michael Balazy, Sylvain Chemtob
Nov 21, 2007·Free Radical Biology & Medicine·Laura ZamboninLaura Landi
Oct 15, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jessica LaroseJean-François Bilodeau
Oct 25, 2016·International Journal of Molecular Sciences·Fereidoon Shahidi, Adriano Costa de Camargo
Mar 4, 2017·Journal of the American Chemical Society·Chryssostomos ChatgilialogluVincent W Bowry
Jan 3, 2019·International Journal of Food Sciences and Nutrition·Wenfeng LiQiang Zhao
Apr 24, 2007·Angewandte Chemie·Ioannis N LykakisChryssostomos Chatgilialoglu
Jan 13, 2011·Organic & Biomolecular Chemistry·Ali El-AgameyDavid J McGarvey
Mar 17, 2018·Lipids in Health and Disease·Samia Hadj AhmedMohamed Hammami
Dec 5, 2019·Experimental Biology and Medicine·Alessandra BolottaMarina Marini
Mar 29, 2011·Organic & Biomolecular Chemistry·Branka MihaljevićChryssostomos Chatgilialoglu
Aug 6, 2019·Oxidative Medicine and Cellular Longevity·Claudia RodriguesAna Cipak Gasparovic
Aug 20, 2011·Journal of the American Chemical Society·Michele MelchiorreCarla Ferreri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.