Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Cancer Genetics and Cytogenetics
Lai-Ching LauSim-Leng Tien

Abstract

Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.

References

Aug 1, 1992·British Journal of Haematology·P JonveauxR Berger
Jan 1, 1992·Annual Review of Immunology·S J Korsmeyer
Sep 13, 1990·The New England Journal of Medicine·G JuliussonG Gahrton
Jan 1, 1986·Cytogenetics and Cell Genetics·I D Dubé, M L Greenberg
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T W McKeithanM O Diaz
Nov 11, 1982·The New England Journal of Medicine·J J YunisA Theologides
Jun 19, 1998·International Journal of Hematology·K KojimaT Sezaki
Jul 21, 1998·Leukemia Research·C N NairS H Advani
Apr 8, 1999·Leukemia & Lymphoma·A CrielC De Wolf-Peeters
Mar 4, 2000·Cancer Genetics and Cytogenetics·S LepretreC Bastard
Nov 29, 2002·Archives of Pathology & Laboratory Medicine·Filiz SenMaher Albitar
Aug 30, 2003·Archives of Pathology & Laboratory Medicine·Francisco Vega, L Jeffrey Medeiros
Feb 25, 2005·The New England Journal of Medicine·Nicholas ChiorazziManlio Ferrarini
Aug 12, 2006·Cancer·Apostolia-Maria TsimberidouMichael J Keating

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.