Occurrence of Vascular Lake Phenomenon as a Predictor of Improved Tumor Response in HCC Patients That Underwent DEB-TACE

Cardiovascular and Interventional Radiology
Rafael Noronha CavalcanteNelson Wolosker

Abstract

To evaluate incidence and predictive factors for the vascular lake phenomenon (VLP), as well as to compare local and overall tumor response in patients with and without VLP induced during DEB-TACE for HCC. A total of 200 consecutive patients with 323 HCC nodules underwent first-session DEB-TACE from 2011 to 2014. Patients were divided in two groups, according to the presence of the VLP during DEB-TACE. Pre- and post-treatment imaging studies (CT or MRI) were performed. Primary endpoint was assessment of tumor response, evaluated by mRECIST. Comparison of response rates between the VLP group and the non-VLP group was performed. Secondary endpoints were the determination of incidence rate and predictive factors for the VLP. The VLP was observed in 39/323 (12.1%) of the nodules treated. At multivariate logistic regression analysis, tumor size ≥3 cm in diameter (OR 13.95; 95% CI 3.60-54.05), presence of a pseudocapsule (OR 6.67; 95% CI 1.45-30.59) and alpha-fetoprotein levels (OR 1.004; 95% CI 1.000-1.007) remained predictive for the VLP occurrence. On a nodule-based analysis (p < 0.001), target lesion response analysis (p = 0.003) and overall response analysis (p = 0.004) the VLP group presented a higher objective response rate th...Continue Reading

References

Jun 11, 2008·Cardiovascular and Interventional Radiology·Keigo OsugaHironobu Nakamura
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Riccardo Lencioni

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Citations

Dec 23, 2017·Internal Medicine·Akira KuriyamaTomohiko Sunami
Oct 12, 2019·World Journal of Gastroenterology : WJG·Breno Boueri AffonsoNelson Wolosker
Jan 28, 2021·Journal of Vascular and Interventional Radiology : JVIR·Fuad NuriliF Edward Boas

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