PMID: 8593935Mar 1, 1996Paper

Occurrence, predictors, and clinical significance of autonomic neuropathy in NIDDM. Ten-year follow-up from the diagnosis

Diabetes
J P TöyryM Uusitupa

Abstract

Little is known about the occurrence and predictive factors of autonomic neuropathy and its relationship to cardiovascular mortality in NIDDM patients, and no long-term follow-up studies including nondiabetic control subjects are available. A total of 133 patients with newly diagnosed NIDDM (70 men) and 144 control subjects (62 men) were examined at baseline and after 5 and 10 years of follow-up. Deep-breathing tests (baseline, 5-year, and 10-year) and active orthostatic tests (5- and 10-year) were performed. Criteria for autonomic neuropathy were parasympathetic (expiration-to-inspiration ratio </- 1.10), sympathetic (systolic blood pressure decrease >/- 30 mmHg in the orthostatic test), and combined autonomic neuropathy (parasympathetic with sympathetic neuropathy). The frequency of parasympathetic neuropathy (NIDDM patients versus control subjects) was 4.9 vs. 2.2% (P = 0.224) at baseline, 19.6 vs. 8.5% (P = 0.017) at 5 years, and 65.0 vs. 28.0% (P < 0.001) at 10 years of follow-up. The frequency of sympathetic neuropathy was 6.8 vs. 5.6% (P = 0.709) at 5 years and 24.4 vs. 9.0% (P = 0.003) at 10 years of follow- up. These figures for combined autonomic neuropathy were 2.1 vs. 1.8% (P = 0.869) at 5 years and 15.2 vs. 4.2% (P...Continue Reading

Citations

Oct 12, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Apr 6, 2000·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A K TurpeinenM I Uusitupa
Jun 27, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Matthias Weck
Feb 10, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Vincenza SpalloneMaria Rosaria Maiello
Feb 23, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Eric A DedertJean C Beckham
Nov 17, 1998·The American Journal of Cardiology·A A SteinbergR F Percy
Dec 18, 2001·International Journal of Cardiology·A J Burger, D Aronson
Sep 6, 2002·Diabetes Research and Clinical Practice·Stephanie G WheelerEdward J Boyko
Feb 15, 2001·European Journal of Internal Medicine·N TentolourisN Katsilambros
Jun 1, 2002·Journal of Diabetes and Its Complications·Jennifer A MayfieldDouglas G Smith
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A GottsäterG Sundkvist
Jul 5, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·H S ChenL T Ho
Sep 13, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H L CollinJ H Meurman
Jul 27, 2001·Diabetes Technology & Therapeutics·D Aronson, A J Burger
Sep 30, 2000·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M J HilzB Neundoerfer
Jan 16, 2002·Menopause : the Journal of the North American Menopause Society·Leo NiskanenJuha Hartikainen
Dec 31, 1998·Journal of Gastroenterology and Hepatology·K I DeenH J De Silva
Nov 1, 2006·International Journal of Clinical Practice·A GirachM Porta
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Claudia R L CardosoGil F Salles
Mar 12, 2008·World Journal of Gastroenterology : WJG·Vladimir KojeckyAles Hep
Oct 1, 2014·International Anesthesiology Clinics·Gwendolyn L Boyd
May 11, 2002·Clinical Physiology and Functional Imaging·Janne VäänänenEsko Länsimies
Dec 16, 1998·Current Opinion in Neurology·P A Low
Oct 1, 2008·Diabetes Research and Clinical Practice·Hung-Ta ChenKam-Tsun Tang
Mar 29, 2014·Clinical Physiology and Functional Imaging·Santeri SeppäläTimo Lakka
Aug 5, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J H MeurmanM Uusitupa
Aug 30, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Ahsan H KhandokerHerbert F Jelinek
Apr 29, 2003·Clinical and Experimental Hypertension : CHE·Shigeru NakanoKenzo Uchida
May 1, 1997·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M B Davidson
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C MeyerH J Teede
Apr 4, 2006·Biological Research for Nursing·Deborah A ChyunFrans J Th Wackers
Aug 26, 2014·Frontiers in Endocrinology·Mika P TarvainenHerbert F Jelinek

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