Ochratoxin A: an antiinsectan metabolite from the sclerotia of Aspergillus carbonarius NRRL 369

Canadian Journal of Microbiology
D T WicklowJ B Gloer

Abstract

Ochratoxin A, a known mycotoxin with demonstrated toxicity to insects, has been isolated from the sclerotia of the fungus Aspergillus carbonarius NRRL 369. The sclerotia, harvested from a solid substrate fermentation of corn kernels at 28 degrees C, produced quantities of ochratoxin A exceeding 50 ppm/g dry weight of sclerotia. Evidence is presented that ochratoxin A accounts for the activity of the methanol extract against larvae of the detritivorous beetle Carpophilus hemipterus (Nitidulidae) (75% reduction in feeding rate) and corn ear worm Helicoverpa zea (50% mortality with 99% reduction in weight gain among surviving larvae) when incorporated into a pinto bean diet at levels less than those occurring naturally in the sclerotia.

References

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Citations

Mar 30, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·P MikusováA Srobárová
Jan 29, 2013·IMA Fungus·Zeljko JurjevićGiancarlo Perrone
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Feb 8, 2006·Canadian Journal of Microbiology·Cesaria E McAlpin, Donald T Wicklow
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Feb 2, 2021·Journal of the Air & Waste Management Association·Kazuhiro HashimotoKoji Yokoyama
Jul 3, 2021·Microorganisms·Alexander Berestetskiy, Qiongbo Hu

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