Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Molecular Nutrition & Food Research
Annie Pfohl-Leszkowicz, Richard A Manderville

Abstract

Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food products. OTA is nephrotoxic and is suspected of being the main etiological agent responsible for human Balkan endemic nephropathy (BEN) and associated urinary tract tumours. Striking similarities between OTA-induced porcine nephropathy in pigs and BEN in humans are observed. International Agency for Research on Cancer (IARC) has classified OTA as a possible human carcinogen (group 2B). Currently, the mode of carcinogenic action by OTA is unknown. OTA is genotoxic following oxidative metabolism. This activity is thought to play a central role in OTA-mediated carcinogenesis and may be divided into direct (covalent DNA adduction) and indirect (oxidative DNA damage) mechanisms of action. Evidence for a direct mode of genotoxicity has been derived from the sensitive 32P-postlabelling assay. OTA facilitates guanine-specific DNA adducts in vitro and in rat and pig kidney orally dosed, one adduct comigrates with a synthetic carbon (C)-bonded C8-dG OTA adduct standard. In this paper, our current understanding of OTA toxicity and carcinogenicity are reviewed. The available evidence suggests that OTA is a genotoxic carcinogen by induction of oxidativ...Continue Reading

References

Jul 1, 1979·Veterinary Pathology·P KroghU Ravnskov
May 1, 1979·Poultry Science·C F ChangP B Hamilton
Nov 1, 1979·Applied and Environmental Microbiology·K HultG Sellyey
Oct 1, 1977·Japanese Journal of Pharmacology·S SuzukiM Yamazaki
Dec 1, 1977·Food and Cosmetics Toxicology·G A Sansing
Jul 1, 1977·The British Veterinary Journal·B J ShreeveA E Wrathall
Jan 1, 1978·IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
May 1, 1978·Poultry Science·M G Prior, C S Sisodia
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG A Sansing
Nov 1, 1978·Toxicology and Applied Pharmacology·S H GilaniM Reily
Jan 1, 1978·Nephron·P W Hall, G J DAMMIN
Jan 1, 1977·International Journal of Cancer. Journal International Du Cancer·Ivan N ChernozemskyN D Kalcheva
Feb 1, 1976·Teratology·R D HoodA W Hayes
Aug 1, 1976·Toxicology and Applied Pharmacology·M H BrownB P Purmalis
Oct 30, 1992·Biochimica Et Biophysica Acta·S Yamamoto
Sep 1, 1992·Zeitschrift für Ernährungswissenschaft·H K Frank
Dec 1, 1992·Journal of Animal Science·R R Marquardt, A A Frohlich
Jan 6, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J H CapdevilaR W Estabrook
Jan 6, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F P Guengerich
May 1, 1992·Archives of Environmental Contamination and Toxicology·R C BraunbergL Friedman
Mar 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Plestina
Mar 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S CeovićM Sarić
Mar 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mato VukelićM Belicza
Jan 1, 1991·Pharmacology & Therapeutics·W L SmithD L DeWitt
Jan 1, 1991·Annual Review of Pharmacology and Toxicology·J C McGiff
Jan 1, 1991·American Journal of Nephrology·V Stefanović, M Polenakovic
Nov 1, 1990·Journal of Comparative Pathology·G S SinghK K Singh
Jan 1, 1990·Kidney International·M L SchwartzmanN G Abraham
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·T E ElingM F Hughes
Sep 15, 1990·Biochemical Pharmacology·R F OmarA D Rahimtula
Sep 1, 1989·Mycopathologia·T LeaF C Størmer
Apr 1, 1989·Journal of Applied Toxicology : JAT·S HagelbergR Fuchs
Feb 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Marcel CastegnaroL Broussolle
Aug 15, 1986·The Biochemical Journal·M L SchwartzmanJ C McGiff
Dec 1, 1988·Archives of Biochemistry and Biophysics·D HenkeT E Eling
Sep 1, 1988·Journal of Animal Science·W E HuffJ A Doerr
Dec 1, 1988·Biochemical Pharmacology·A D RahimtulaH Bartsch
Feb 1, 1988·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·M GareisB Gedek
Jul 1, 1988·Food Additives and Contaminants·Theodora Petkova-BocharovaMarcel Castegnaro
Oct 1, 1987·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·J Bauer, M Gareis
Jan 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y FukuiH Nagano
May 1, 1986·Veterinary Pathology·C HanikaJ Tuite
Aug 15, 1985·Biochemical and Biophysical Research Communications·T KamatakiR Kato
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J A HunterM J Holtzman
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·F EllingF C Størmer
Oct 1, 1985·Food Additives and Contaminants·Theodora Petkova-Bocharova, Marcel Castegnaro
Oct 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Kumagai
Jan 1, 1985·Journal of Toxicology and Environmental Health·A F SteinR B Harvey
Dec 1, 1971·Archives of Biochemistry and Biophysics·F S Chu
May 1, 1974·Toxicology and Applied Pharmacology·I C MunroH C Grice
Feb 1, 1974·Teratology·A W HayesH L Lee
Feb 1, 1974·Biochemical Pharmacology·M Y Chu, M L Hoovis
Aug 1, 1974·Food and Cosmetics Toxicology·R C DosterN E Pawlowski
Jan 1, 1973·Veterinary Pathology·G M SzczechJ Tuite
Jan 1, 1973·Veterinary Pathology·G M SzczechR Caldwell
Oct 1, 1971·Food and Cosmetics Toxicology·I F Purchase, J J Van der Watt
Aug 1, 1969·Biochemical Pharmacology·M J Pitout
Jan 1, 1983·Annual Review of Physiology·J A GustafssonP Skett
Jun 15, 1984·Toxicology and Applied Pharmacology·W O BerndtJ M Baggett
Nov 1, 1984·European Journal of Cancer & Clinical Oncology·P Hilgard, H Burkert
Jul 1, 1984·Applied and Environmental Microbiology·R FuchsR Plestina
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Aug 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Oct 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L E Appelgren, R G Arora
Feb 1, 1984·Toxicology and Applied Pharmacology·G A BoormanM I Luster
Jan 1, 1983·Applied and Environmental Microbiology·D VeseláR Jelínek
Jan 1, 1983·Cancer Letters·M Arai, T Hibino
Jun 1, 1982·Applied and Environmental Microbiology·C E HansenF C Størmer
Jun 15, 1982·Toxicology and Applied Pharmacology·S Kumagai, K Aibara
Sep 1, 1982·Poultry Science·P B HamiltonR D Wyatt
Oct 1, 1982·Applied and Environmental Microbiology·O StørenF C Størmer
Jan 1, 1981·Toxicology and Applied Pharmacology·G M Szczech, R D Hood
Apr 1, 1981·Applied and Environmental Microbiology·H D HaubeckR Röschenthaler
Dec 1, 1981·Applied and Environmental Microbiology·F C StørmerA J Aasen
Dec 1, 1981·Food and Cosmetics Toxicology·P GaltierJ L Charpenteau
Jun 1, 1980·Experimental and Molecular Pathology·V G LockardR M O'Neal
Mar 1, 1980·Applied and Environmental Microbiology·C F Chang, P B Hamilton
May 1, 1980·Toxicology Letters·E E CreppyG Dirheimer
May 1, 1980·Applied and Environmental Microbiology·F C Størmer, J I Pedersen
Jun 1, 1980·Poultry Science·M G PriorC S Sisodia
Jan 1, 1980·Toxicology·R D PhillipsW L Williams
Jan 1, 1994·Renal Physiology and Biochemistry·Michael Gekle, S Silbernagl
Apr 1, 1995·Journal of Biochemical Toxicology·P RoyA P Kulkarni
Jan 1, 1995·Natural Toxins·J Fink-GremmelsM J Blom
Aug 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J GoetzlW L Smith
May 1, 1995·Food Additives and Contaminants·C MiccoA Ambruzzi
Mar 30, 1995·Chemico-biological Interactions·Yann GrosseAnnie Pfohl-Leszkowicz
Jan 1, 1994·Advances in Pharmacology·R Munday
Jan 1, 1994·Natural Toxins·R C BraunbergL Friedman
Nov 1, 1993·American Journal of Medical Genetics·X Wei, K K Sulik
Jan 1, 1993·Nephron·N Di PaoloM Di Paolo
Jan 29, 1993·Cell·L L LinR J Davis
Apr 1, 1993·Trends in Genetics : TIG·B Vogelstein, K W Kinzler
Aug 1, 1995·Mycopathologia·F E JonsynR G Hendrickse
Feb 9, 1996·Biochemical Pharmacology·R F OmarA D Rahimtula
Feb 1, 1996·Applied and Environmental Microbiology·H XiaoA A Frohlich
Feb 1, 1996·Regulatory Toxicology and Pharmacology : RTP·W K Lutz, D Gaylor
Jun 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ThuvanderI Gadhasson
Jan 1, 1996·Kidney International·H SugiyamaA Ota
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ThuvanderM Olsen
Aug 1, 1996·Food Additives and Contaminants·B Zimmerli, R Dick
Apr 28, 1997·Toxicology Letters·Bozica RadićA Lucić
Jan 1, 1997·Archives of Toxicology·Gisela H DegenG Dirheimer
Jul 1, 1997·Toxicology and Applied Pharmacology·S LiG Crow
Apr 29, 1998·Kidney International·S E ThomasR J Johnson
Jun 25, 1998·International Journal of Cancer. Journal International Du Cancer·Marcel CastegnaroH Bartsch
Aug 5, 1998·European Journal of Epidemiology·D TonchevaS Stojanova
Oct 17, 1998·Toxicology and Applied Pharmacology·Michael GekleH Schramek
Nov 3, 1998·Lancet·Peter G MantleM Dobrota
Nov 26, 1998·Food Additives and Contaminants·K Jørgensen
Nov 26, 1998·Food Additives and Contaminants·P M ScottT Kuiper-Goodman
Dec 16, 1998·Natural Toxins·I P HallénA Oskarsson
Feb 16, 1999·Journal of Applied Toxicology : JAT·M A Abdel-WahhabM S Arbid
May 8, 1993·Health Care Analysis : HCA : Journal of Health Philosophy and Policy·B Barratt-Boyes
May 1, 1999·The Journal of Biological Chemistry·H KusuharaHitoshi Endou
Jun 11, 1999·The American Journal of Physiology·Douglas H SweetJohn B Pritchard
Jul 8, 1999·Cancer Letters·Y L CheungGraeme I Murray
Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E DoppD Schiffmann
Nov 24, 1999·Chemical Research in Toxicology·Ivan G GillmanRichard A Manderville
Dec 11, 1999·Toxicology Letters·M PeraicaBozica Radić
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Mar 4, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·A DörrenhausWolfram Föllmann
Mar 11, 2000·Environmental and Molecular Mutagenesis·C El AdlouniAnnie Pfohl-Leszkowicz
Apr 25, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Stoycho D StoevD Pavlov
May 10, 2000·American Journal of Veterinary Research·K N KhanR K Harris
May 24, 2000·Mycopathologia·J L RichardS L Liska
Jun 10, 2000·Journal of Veterinary Pharmacology and Therapeutics·Ernst Petzinger, K Ziegler
Jul 11, 2000·Journal of Agricultural and Food Chemistry·Terry VrabchevaErwin Märtlbauer
Jul 21, 2000·Chemico-biological Interactions·S Obrecht-Pflumio, G Dirheimer
Sep 15, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Stoycho D StoevPeter G Mantle
Dec 29, 2000·Archives of Toxicology·I Studer-RohrDaniel R Dietrich
Jan 3, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·Herbert ZepnikWolfgang Dekant
Feb 15, 2001·Chemical Research in Toxicology·J C GautierRobert J Turesky
May 4, 2001·Veterinary Research Communications·Stoycho D StoevE E Creppy
May 8, 2001·Food Additives and Contaminants·M A SkaugO D Saugstad
May 23, 2001·Free Radical Biology & Medicine·J C GautierRobert J Turesky
Jun 21, 2001·Chemical Research in Toxicology·F P Guengerich
Jul 20, 2001·British Journal of Cancer·M C McFadyenGraeme I Murray
Jul 27, 2001·Food Additives and Contaminants·V G CurtuiErwin Märtlbauer
Sep 8, 2001·Archives of Toxicology·M A StanderV Sewram
Sep 14, 2001·Mycopathologia·M A SkaugF C Størmer
Sep 18, 2001·Chemical Research in Toxicology·M W CalcuttRichard A Manderville
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ThuvanderM Olsen
Jan 10, 2002·Biochemical and Biophysical Research Communications·Yasuna KobayashiToshinori Yamamoto
Feb 5, 2002·Annual Review of Physiology·Frans G M RusselRemon A M H van Aubel
Feb 7, 2002·Journal of Agricultural and Food Chemistry·Kerstin Gross-SteinmeyerManfred Metzler
Mar 2, 2002·Carcinogenesis·Po-Hsiung LinJames A Swenberg
Mar 5, 2002·Pathologie-biologie·Plamen DimitrovW J J Karmaus
Mar 20, 2002·Cancer Causes & Control : CCC·Gary G Schwartz
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Susan C N BuistCurtis D Klaassen
Apr 3, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Stoycho D StoevPeter G Mantle
Jun 14, 2002·Biochimica Et Biophysica Acta·Ellappan BabuHitoshi Endou
Jun 18, 2002·Journal of Cellular and Molecular Medicine·A OrtizJ Egido
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·V EhrlichSiegfried Knasmüller
Jun 19, 2002·International Archives of Occupational and Environmental Health·Ivo IavicoliMarina Miraglia
Jul 2, 2002·Veterinary Research Communications·Stoycho D StoevPeter G Mantle
Sep 5, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Alexandra H HeussnerDaniel R Dietrich
Oct 19, 2002·Biochimica Et Biophysica Acta·G J SchaafJohanna Fink-Gremmels
Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·Krisztina BiróJohanna Fink-Gremmels
Dec 17, 2002·Chemical Research in Toxicology·Jian DaiRichard A Manderville
Dec 19, 2002·American Journal of Physiology. Renal Physiology·Douglas H SweetJohn B Pritchard
Jan 4, 2003·Photochemistry and Photobiology·Mark E BrowRichard A Manderville
Jan 22, 2003·Advanced Drug Delivery Reviews·Alfred H Schinkel, Johan W Jonker
Mar 8, 2003·Food Additives and Contaminants·K Jørgensen, J S Jacobsen
Mar 27, 2003·Journal of the American Chemical Society·Jian DaiRichard A Manderville
Apr 22, 2003·International Journal of Cancer. Journal International Du Cancer·Woo-Chan SonKyung-Sun Kang
Apr 25, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ana MiljkovicPeter G Mantle
Jul 10, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G MüllerH Köhler
Jul 29, 2003·Pflügers Archiv : European journal of physiology·Hermann Koepsell, Hitoshi Endou
Sep 19, 2003·Archives of Toxicology·József PetrikIvana Cepelak
Aug 1, 1965·The American Journal of Medicine·P W HALLJ GAON
Oct 14, 2003·Toxicology and Applied Pharmacology·Herbert ZepnikWolfgang Dekant
Oct 16, 2003·Trends in Pharmacological Sciences·Masataka MajimaIzumi Hayashi
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yukihiro EsakaMasashi Goto
Jan 9, 2004·The New England Journal of Medicine·Patricia D Wilson
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Qinzhong ChenTomohiko Koyanagi
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Dawn M CarnellSteven A Everett
Feb 18, 2004·Chemical Research in Toxicology·Angela MallyWolfgang Dekant
Mar 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Robert J Turesky, Paul Vouros
Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Y Simarro DoortenJohanna Fink-Gremmels
Apr 8, 2004·American Journal of Physiology. Renal Physiology·Geri L Youngblood, Douglas H Sweet
Apr 15, 2004·Journal of Agricultural and Food Chemistry·Terry VrabchevaSylviane Dragacci
May 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Susan C N Buist, Curtis D Klaassen
Sep 18, 2004·Cancer Letters·Shan ZhaAngelo M De Marzo
Sep 21, 2004·Chemical Research in Toxicology·Virginie FaucetRichard A Manderville
Nov 9, 2004·Trends in Pharmacological Sciences·Hiroki MiyazakiHitoshi Endou
Dec 15, 2004·Urology·Burcin TunaZiya Kirkali
Dec 23, 2004·Accounts of Chemical Research·Jian DaiJohn D Simon
Jan 7, 2005·Molecular Nutrition & Food Research·Michael GekleGerald Schwerdt
Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nadezhda N BarvitenkoRoy E Weber
Feb 15, 2005·Clinical Biochemistry·Srebrena AtanasovaVictor W Armstrong
Mar 4, 2005·Critical Reviews in Toxicology·Evelyn O'Brien, Daniel R Dietrich
Mar 24, 2005·Acta Veterinaria Hungarica·B FazekasMelinda Kovács
Apr 19, 2005·Chemical Research in Toxicology·Jian DaiRichard A Manderville
Jul 16, 2005·Food Additives and Contaminants·S A NavasD B Rodriguez-Amaya
Jul 19, 2005·Chemical Research in Toxicology·Robert J Turesky
Jul 19, 2005·Chemical Research in Toxicology·Richard A Manderville
Sep 6, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Alexandra H HeussnerEvelyn O'Brien
Oct 1, 2005·The Journal of Pharmacology and Experimental Therapeutics·Daniel A J BowJohn B Pritchard
Oct 26, 2005·Archives of Toxicology·J SchrickxJ Fink-Gremmels
Nov 19, 2005·Chemico-biological Interactions·Diana RingotY Larondelle
Nov 23, 2005·Molecular Nutrition & Food Research·Hennicke G KampRobert J Turesky
Dec 8, 2005·Food Additives and Contaminants·Kevin Jørgensen
Dec 8, 2005·Food Additives and Contaminants·R Fuchs, M Peraica
Dec 8, 2005·Food Additives and Contaminants·Peter G MantleSandra Nestler
Dec 8, 2005·Food Additives and Contaminants·Annie Pfohl-Leszkowicz, M Castegnaro
Dec 8, 2005·Food Additives and Contaminants·P M Scott
Jan 7, 2006·Wiener klinische Wochenschrift·Marica Miletić-MedvedM Peraica
Feb 21, 2006·Biochemical and Biophysical Research Communications·Maria Emileva Krasteva, Elena Ivanova Georgieva
May 23, 2006·Molecular Nutrition & Food Research·Marcel CastegnaroAnnie Pfohl-Leszkowicz
Sep 19, 2006·Chemical Research in Toxicology·Mariana TozlovanuRichard A Manderville
Apr 1, 1985·Avian Pathology : Journal of the W.V.P.A·P Dwivedi, R B Burns
Apr 1, 1999·Environmental Toxicology and Pharmacology·E PinelliAnnie Pfohl-Leszkowicz
Mar 1, 2003·Mycotoxin Research·Gisela H DegenC Grüner
Jun 1, 2000·Mycotoxin Research·A WeidenbachErnst Petzinger

Citations

Nov 29, 2012·Analytical and Bioanalytical Chemistry·Betty C GalarretaFrançois Lagugné-Labarthet
Feb 15, 2013·Analytical and Bioanalytical Chemistry·Zhijun GuoErkang Wang
Feb 26, 2011·Applied Microbiology and Biotechnology·Samrat Roy ChoudhuryA Goswami
Nov 17, 2009·Clinical Reviews in Allergy & Immunology·Andrea BorchersM Eric Gershwin
Jan 17, 2009·Genes & Nutrition·Xiangnan ZhangGerald Rimbach
Dec 1, 2009·Mycotoxin Research·Erwin MärtlbauerElisabeth Schneider
Apr 23, 2013·Mycotoxin Research·Jelka PleadinMario Mitak
Sep 7, 2011·Journal of Agricultural and Food Chemistry·Hector RodriguezEmilia Garcia-Moruno
Jul 5, 2011·Chemical Research in Toxicology·Tingting TuMichael L Gross
Dec 1, 2011·Chemical Research in Toxicology·K Hadjeba-MedjdoubRichard A Manderville
Nov 8, 2011·Chemical Research in Toxicology·Annie Pfohl-Leszkowicz, Richard A Manderville
Feb 9, 2008·Nature Clinical Practice. Urology·Vladisav Stefanovic, Zoran Radovanovic
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Pierre MandaGérard Fourny
Dec 17, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·T Kuiper-GoodmanS Hayward
Sep 16, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Stoycho D StoevP A Steenkamp
Oct 13, 2011·Natural Product Research·Pierluigi PlastinaBartolo Gabriele
Sep 14, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·I PolisenskaP Macharackova
May 31, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·J TamI D K Richard
May 21, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M G AnderssonP Häggblom
Jul 19, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L RibonnetY Larondelle
Jul 26, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M StorariG A L Broggini
Aug 30, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jelka PleadinSalvatore Milone
May 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·C CavinB Schilter
May 31, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daisuke HibiTakashi Umemura
Apr 11, 2008·Annual Review of Nutrition·Lynnette R Ferguson, Martin Philpott
Jul 22, 2011·Journal of Toxicology·M Marin-KuanB Schilter
Apr 1, 2009·International Journal of Molecular Sciences·Iwona Wilk-Zasadna, Maria Minta
Sep 29, 2011·International Journal of Molecular Sciences·Kunio Doi, Koji Uetsuka
Jan 9, 2013·International Journal of Molecular Sciences·Yan-Der HsuuwJau-Song Yu
Apr 1, 2010·Toxins·André el Khoury, Ali Atoui
Apr 1, 2010·Toxins·Lalini Reddy, Kanti Bhoola
Apr 1, 2010·Toxins·Pavlina YordanovaPlamen Dimitrov
Apr 1, 2010·Toxins·Gianluca LucchettaE Angelini
May 1, 2010·Toxins·Luís AbrunhosaArmando Venâncio
May 1, 2010·Toxins·F Javier CabañesGemma Castellá
Jun 1, 2010·Toxins·Sofia Cancela DuarteCeleste Matos Lino
Jun 1, 2010·Toxins·Lauy Al-AnatiErnst Petzinger
Jun 1, 2010·Toxins·Naohiko AnzaiHitoshi Endou
Jul 22, 2010·Toxins·Jamie E Jennings-GeeGary G Schwartz
Jun 1, 2010·Toxins·Jorn C C Yu, Edward P C Lai
Jul 1, 2010·Toxins·Gianni BattaconeGiuseppe Pulina
Aug 1, 2010·Toxins·M PeraicaBogdan Cvjetković
Sep 1, 2010·Toxins·Ingrid BazinMiguel Lopez-Ferber
Jan 25, 2013·Toxins·Fiorenza MinerviniGiovanni Michele Lacalandra
Jun 26, 2013·Toxins·Meike HeurichIbtisam E Tothill
Sep 21, 2013·Toxins·Vladimir OstryJiri Ruprich
Oct 25, 2013·Toxins·Valeria SorrentiFabio Galvano
Nov 8, 2013·Toxins·Amina RhouatiJean-Louis Marty
Nov 30, 2013·Toxins·Ingrid BazinAnnie Pfohl-Leszkowicz
Dec 20, 2013·Toxins·Zheng HanAlfons Callebaut
Jul 11, 2013·World Journal of Gastroenterology : WJG·Raphael J F Felizardo, Niels O S Câmara
Jan 16, 2014·Annual Review of Food Science and Technology·Felicia WuJames J Pestka
Dec 7, 2013·Analytical and Bioanalytical Chemistry·Wassim Hadj Ali, Valérie Pichon
Feb 13, 2014·Toxins·Frederick T Guilford, Janette H Hope
Nov 5, 2014·Jundishapur Journal of Microbiology·Parvin DehghanMojtaba Akbari
Mar 7, 2014·Fungal Genetics and Biology : FG & B·Samina AshiqBashir Ahmad
May 13, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Firdevs MorKemal Uran
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Arthur P GrollmanBojan Jelaković
Jun 3, 2014·BMC Genomics·Qiu DaiKunlun Huang
Jun 7, 2014·Applied Biochemistry and Biotechnology·Bansi D MalhotraChandan Singh
Jul 25, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ariane VettorazziA López de Cerain
Jan 12, 2011·Analytical and Bioanalytical Chemistry·Florence Chapuis-HugonValérie Pichon
Dec 3, 2014·International Journal of Food Microbiology·Giancarlo PerroneJos Houbraken
Aug 17, 2014·Toxicon : Official Journal of the International Society on Toxinology·Lada RumoraMaja Segvić Klarić
Aug 26, 2014·Research in Veterinary Science·Chiara BernardiniMonica Forni
Oct 23, 2014·Analytical and Bioanalytical Chemistry·Fabien Brothier, Valérie Pichon
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Lada Rumora, Tihana Zanić Grubisić
Apr 3, 2012·Bulletin of Environmental Contamination and Toxicology·Jelka PleadinMate Brstilo
Dec 20, 2014·Toxins·Frantisek MalirTomas Roubal
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
May 31, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Frantisek MalirTomas Roubal
Nov 25, 2015·Food Additives & Contaminants. Part B, Surveillance·Alperen Tosun, Sibel Ozden
Jan 5, 2016·International Journal of Hygiene and Environmental Health·H FrommeC Gottschalk
Nov 14, 2015·Journal of Food Science·Hyun Jung Lee, Dojin Ryu
Jan 22, 2013·International Journal of Food Microbiology·Abdelhamid AbbasAlan D W Dobson
Apr 18, 2008·Kidney International·Frédéric D DebelleJoëlle Nortier
Jul 4, 2012·Toxicology·Jente BoonenBart De Spiegeleer
Nov 1, 2011·Toxicology Letters·Chit Shing Jackson WooHani El-Nezami
Aug 27, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Laura-Ana CorcueraAdela López de Cerain
Sep 7, 2011·International Journal of Food Microbiology·María Lorena PonsoneSofía Chulze
Sep 9, 2011·International Journal of Food Microbiology·Jessica Gil-SernaCovadonga Vazquez
Aug 13, 2011·Journal of Chromatography. a·Elisabeth Viktoria ReiterEbrahim Razzazi-Fazeli
Jul 23, 2011·Journal of Bioscience and Bioengineering·Luís AbrunhosaJosé António Teixeira
May 3, 2011·International Journal of Food Microbiology·A Crespo-SempereP V Martínez-Culebras
Jun 15, 2011·International Journal of Food Microbiology·A Crespo-SempereL González-Candelas
Aug 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ariane VettorazziA López de Cerain
Dec 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·João G CostaNuno G Oliveira
May 22, 2010·Journal of Chromatography. a·Wassim Hadj AliValérie Pichon
Jul 6, 2014·Critical Reviews in Food Science and Nutrition·Luís AbrunhosaArmando Venâncio
Nov 19, 2009·Bioorganic & Medicinal Chemistry·Benedikt CramerHans-Ulrich Humpf
Nov 10, 2009·Pathologie-biologie·Vladisav StefanovicD Toncheva
Oct 15, 2009·Toxicon : Official Journal of the International Society on Toxinology·Pinar ErkekogluBelma Kocer Giray
Mar 8, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhaowei ZhangPeiwu Li
Oct 13, 2009·International Journal of Food Microbiology·Jessica Gil-SernaBelén Patiño
Sep 2, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G RanaldiC Murgia
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Simona CosimiFelipe Cortés
Aug 4, 2015·Environment International·Ellen HeyndrickxSarah De Saeger
Jun 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C Boesch-SaadatmandiGerald Rimbach
Dec 1, 2015·International Journal of Food Microbiology·Vincenzo LippolisGiancarlo Perrone
Mar 18, 2016·Environmental Toxicology and Pharmacology·L N CariddiA M Dalcero
Oct 31, 2015·Néphrologie & thérapeutique·Joëlle NortierJean-Louis Vanherweghem
Jul 17, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Amy L BrownPeter G Mantle
May 29, 2007·Journal of Pharmaceutical and Biomedical Analysis·Rosa VatinnoFrancesco Palmisano
Dec 11, 2007·American Journal of Industrial Medicine·Robin Taylor WilsonMustafa Dosemeci
Aug 31, 2007·Molecular Nutrition & Food Research·Annie Pfohl-LeszkowiczVladislav Stefanovic
Sep 15, 2007·Molecular Nutrition & Food Research·Gisela H DegenStephanie Stock
Jul 12, 2008·Molecular Nutrition & Food Research·Michael HabermeyerGerhard Eisenbrand
Jan 6, 2009·Molecular Nutrition & Food Research·Annie Pfohl-LeszkowiczRichard A Manderville
Dec 26, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Zheqian ZhangKehe Huang
Aug 11, 2007·Molecular Nutrition & Food Research·Ana-Marija DomijanRadovan Fuchs
Feb 19, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Taihua LiMin-Gon Kim
Aug 18, 2012·Journal of Applied Microbiology·S Roy Choudhury, A Goswami
Aug 14, 2012·Electrophoresis·Federico J V GomezMaría F Silva
Jan 8, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Frantisek MalirEva Novotna
Jun 24, 2014·Risk Analysis : an Official Publication of the Society for Risk Analysis·Travis Bui-Klimke, Felicia Wu
Mar 24, 2016·International Journal of Environmental Research and Public Health·Carla ViegasSusana Viegas
Nov 26, 2009·Journal of Applied Toxicology : JAT·A GürbayG Tekinalp
Mar 30, 2016·Toxins·Chit Shing Jackson Woo, Hani El-Nezami
Jun 23, 2015·Journal of Cellular Biochemistry·Shanel RaghubeerAnil Chuturgoon
Nov 13, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Kra Brou Didier KedjeboDidier Montet
Oct 1, 2013·International Journal of Occupational and Environmental Health·S V M Maharaj
Apr 5, 2016·Mycotoxin Research·Pierre MandaDjédjé Sébastien Dano
Jul 25, 2013·Biosensors & Bioelectronics·Weihua HuChang Ming Li
Sep 27, 2014·Journal of Applied Toxicology : JAT·Sara ParadellsMª Ángeles Garcia-Esparza
Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Evelien Van de PerreBruno De Meulenaer
Jun 27, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Loganathan GayathriMohammad A Akbarsha
Mar 26, 2015·Toxicon : Official Journal of the International Society on Toxinology·Raimo MikkolaMirja S Salkinoja-Salonen
Mar 16, 2011·Critical Reviews in Toxicology·Sofia Cancela DuarteCeleste Matos Lino
Jul 3, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Vita Di StefanoGiacomo Dugo
Apr 14, 2015·Environmental Toxicology and Pharmacology·L N CariddiA M Dalcero
Jul 10, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Laura-Ana CorcueraLópez de Cerain A
Aug 3, 2013·Meat Science·Nina PeršiSalvatore Milone
Sep 8, 2012·Food Chemistry·Beatriz Prieto-SimónHiroshi Saiki
Feb 1, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shujuan HuangXianghong Zhang
May 6, 2014·International Journal of Food Microbiology·A Crespo-SempereL González-Candelas
Jun 17, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maja Segvić KlarićLada Rumora
Jul 23, 2013·Toxicon : Official Journal of the International Society on Toxinology·Sevtap AydinBelma Kocer Giray
Apr 5, 2014·International Journal of Food Microbiology·Antonia GalloGiancarlo Perrone
Dec 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Laura-Ana CorcueraLópez de Cerain A
Apr 29, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A G Marroquín-CardonaA W Hayes
Jun 22, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H W WangN Zheng
Sep 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Periasamy Ramyaa, Viswanadha Vijaya Padma
Oct 9, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Annie Pfohl-LeszkowiczJohanna Fink-Gremmels
Jun 12, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ariane VettorazziLópez de Cerain A
Sep 26, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Kai XiaWentao Xu
Jul 23, 2011·Journal of Pharmacological Sciences·Promsuk JutabhaHiroyuki Sakurai
Jun 11, 2014·Food Additives & Contaminants. Part B, Surveillance·Abdalla A Elbashir, Salah Eldeen A Ali
Jul 16, 2016·Archives of Toxicology·Peyman AkbariJohanna Fink-Gremmels
Jul 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y N GaoN Zheng
Jul 19, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ana VulićJelka Pleadin
May 16, 2014·Journal of Agricultural and Food Chemistry·Cristina GiovannoliClaudio Baggiani
Sep 29, 2011·The Journal of Physical Chemistry. B·Andrea L MillenStacey D Wetmore
Sep 8, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Lijun QiZhengxing Chen
Oct 22, 2016·Chemical Research in Toxicology·Richard A Manderville, Stacey D Wetmore
Dec 2, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jelka PleadinDragan Kovačević
Dec 20, 2014·Toxicology and Industrial Health·E Rahimi
Sep 27, 2012·Toxicology and Industrial Health·Mansour A Al-Hazmi
Jan 24, 2017·Food Additives & Contaminants. Part B, Surveillance·Ljilja TorovićMilka Popović
Jan 26, 2017·Frontiers in Microbiology·Vania C LiuzziGiuseppina Mulè
May 17, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Gisela H Degen
Nov 27, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gerald SchwerdtMichael Gekle
Dec 13, 2016·The Journal of Veterinary Medical Science·Valentina MeucciLuigi Intorre
Mar 7, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen Chen, Felicia Wu
Feb 23, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·M B CoronelS Marin
Jun 8, 2017·Journal of Cellular Biochemistry·Sara DamianoRoberto Ciarcia
Jun 6, 2017·Journal of the Science of Food and Agriculture·Jakub TomanAnnie Pfohl-Leszkowicz
Jan 11, 2017·Critical Reviews in Food Science and Nutrition·Pranav TripathiSeema Nara
Dec 23, 2015·Toxins·Tai Hwan Ha
Apr 6, 2018·Journal of Food Protection·Chunyan SuWeiwei Gao
May 3, 2018·Journal of Food Protection·Bandana DhunganaMelanie Caffe-Treml
Oct 17, 2017·Journal of Cellular Physiology·Mohammad MohajeriAmirhossein Sahebkar
Jun 8, 2018·Journal of the Science of Food and Agriculture·Aliki XanthopoulouDimosthenis Kizis
Jul 7, 2018·Journal of Veterinary Research·Katarzyna PietruszkaPiotr Jedziniak
Jul 17, 2016·Applied and Environmental Microbiology·Massimo FerraraAntonia Gallo
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Annie Pfohl-Leszkowicz
Dec 14, 2018·Human & Experimental Toxicology·D RašićM Peraica
Sep 25, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuan YangXiaoyun He
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Arthur P Grollman, Bojan Jelaković
Dec 20, 2018·International Journal of Veterinary Science and Medicine·Amany M DiabNagwan El-Habashi
May 8, 2019·Nucleic Acids Research·Guohua XuMaili Liu
Jul 18, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Boyang ZhangWentao Xu
Oct 10, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Frantisek MalirVlastimil Dohnal
Jun 22, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hervé RobertIsabelle P Oswald
Oct 28, 2019·Toxins·Hafize Aysin AkpinarIbrahim Yaman
Sep 29, 2019·Occupational and Environmental Medicine·Evangelia-Theano SmpokouBen Caplin
Jan 4, 2020·Journal of Cellular Physiology·Sara DamianoRoberto Ciarcia
May 19, 2020·Food Additives & Contaminants. Part B, Surveillance·Nina KudumijaJelka Pleadin
Jul 1, 2020·Environmental Science and Pollution Research International·Mahmoud H El-DeepBilal Ahamad Paray
Oct 20, 2017·Food Additives & Contaminants. Part B, Surveillance·Jelka PleadinKsenija Markov
Oct 20, 2017·Food Additives & Contaminants. Part B, Surveillance·Ljilja Torović
Sep 4, 2020·Biological & Pharmaceutical Bulletin·Min Cheol PyoKwang-Won Lee
Jul 19, 2020·Annual Review of Nutrition·William D FiersIliyan D Iliev
Feb 12, 2017·Oncology Reports·Mowaffaq Adam Ahmed AdamDoblin Anak Sandai
Nov 27, 2016·The Journal of Microbiology·Hyeonheui HamTheresa Lee
Apr 20, 2017·Toxins·Firdevs MorOzlem Ozmen
Jun 6, 2018·Frontiers in Molecular Biosciences·Priya KalraTarun K Sharma
Apr 27, 2018·Mycotoxin Research·Jakub TomanFrantisek Malir
Jul 13, 2018·Frontiers in Microbiology·Wenying ChenXiao L Shen
Jul 25, 2019·Mikrochimica Acta·Zeki Semih PehlivanMeral Yüce
Jan 31, 2020·Frontiers in Microbiology·Zsolt RádulyLászló Csernoch
Apr 25, 2020·Antioxidants·Sara DamianoRoberto Ciarcia
May 5, 2017·Chemistry, an Asian Journal·Dik-Lung MaChung-Hang Leung
Jul 8, 2016·Toxins·Frantisek MalirJakub Toman
Oct 13, 2018·Pakistan Journal of Biological Sciences : PJBS·Nazieh I Al Khalaileh