PMID: 883089May 1, 1977

Ochratoxin A and citrinin induced nephrosis in Beagle dogs. II. Pathology

Veterinary Pathology
D N KitchenJ Tuite

Abstract

Beagle dogs were given ochratoxin A (0.1 and 0.2 mg/kg) and citrinin (5 and 10 mg/kg) alone and in two dose combinations for 14 days. The gross lesions included focal peritonitis and intestinal intussusceptions in dogs given citrinin. Changes in the kidneys of dogs given ochratoxin A were degeneration and necrosis with desquamation of tubular epithelial cells, primarily in the straight segment of the proximal tubules. Dogs given 10 mg/kg citrin had similar changes in the distal tubules and collecting ducts. Dogs given combined doses of citrinin and ochratoxin A had degeneration and necrosis in proximal and distal tubules, and in thin segments and the collecting ducts; there were desquamated cells and granular casts in the lumina. Dogs given ochratoxin A had necrosis of lymphoid tissues in the spleen, tonsil, thymus, peripheral lymph nodes and lymph nodules of the ileum, colon and rectum. There was ulceration of the mucosa of the intestine in dogs given large combined doses of ochratoxin A and citrinin.

References

Dec 1, 1971·Archives of Biochemistry and Biophysics·F S Chu
May 1, 1974·Toxicology and Applied Pharmacology·I C MunroH C Grice
Aug 1, 1974·Food and Cosmetics Toxicology·W W CarltonJ Tuite
May 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·F S ChuC C Chang
Jan 1, 1973·Veterinary Pathology·G M SzczechJ Tuite
Jan 1, 1973·Veterinary Pathology·G M SzczechR Caldwell
Oct 1, 1971·Food and Cosmetics Toxicology·I F Purchase, J J Van der Watt
Nov 1, 1971·Poultry Science·H ChoudhurvG Semeniuk
May 29, 1970·Science·J H Moore, B Truelove
Feb 1, 1971·Toxicology and Applied Pharmacology·E WeiC H Hine
Dec 1, 1968·Food and Cosmetics Toxicology·I F Purchase, J J Theron
Sep 1, 1969·Toxicology and Applied Pharmacology·G F GebhartC L Mitchell
Apr 1, 1966·The Journal of Pathology and Bacteriology·J J TheronW Nel

Citations

Dec 1, 1977·Food and Cosmetics Toxicology·G A Sansing
Aug 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Mar 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P Krogh
Sep 25, 2001·Toxicology·H S Hussein, J M Brasel
Sep 21, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ting-Shuan WuBiing-Hui Liu
Nov 6, 2013·Toxins·Maja Segvić KlarićMaja Peraica
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG A Sansing
Mar 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·L Al-Anati, E Petzinger
Jun 24, 2014·Risk Analysis : an Official Publication of the Society for Risk Analysis·Travis Bui-Klimke, Felicia Wu
Sep 8, 2005·Veterinary Immunology and Immunopathology·Sandrine Bouhet, Isabelle P Oswald
Aug 1, 1978·Food and Cosmetics Toxicology·W H Jordan, W W Carlton
Dec 1, 1981·Food and Cosmetics Toxicology·N A MehdiJ Tuite
Dec 13, 2016·The Journal of Veterinary Medical Science·Valentina MeucciLuigi Intorre
Oct 2, 2009·Toxicology and Industrial Health·Robert W Coppock, Barry J Jacobsen
Sep 8, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Cathy A BrownScott A Brown
Aug 10, 2011·Laboratory animal research·Dongsun ParkYun-Bae Kim
Jan 1, 1994·Natural Toxins·R C BraunbergL Friedman
May 1, 1986·Veterinary Pathology·C HanikaJ Tuite

Related Concepts

Benzopyrans
Citrinin
Dog Diseases
Canis familiaris
Ileum
Intussusception
Kidney
Lymph Nodes
Nephrosis
Ochratoxins

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