Ochratoxin A and citrinin nephrotoxicity in New Zealand White rabbits: an ultrastructural assessment

Mycopathologia
Manoj KumarRajendra Damu Patil

Abstract

In the present investigation, ochratoxin A (OTA) (0.75 mg/kg feed) and citrinin (CIT) (15 mg/kg feed) were fed alone and in combination to young growing New Zealand White rabbits for 60 days to evaluate renal ultrastructural alterations. The severity and intensity of renal ultrastructural changes varied with the type of the treatment, and predominant and consistent lesions were recorded in the proximal convoluted tubule (PCT) lining cells. The significant changes in mitochondria, the most affected cell organelle in all the treatment groups, included mitochondrial disintegration and distortion, pleomorphism, cluster formation and misshapen appearance such as signet ring, dumbbell, cup and U shapes. Intra-cisternal sequestrations of involuting mitochondria, and thickening of basal layer of PCT epithelial cells with partial detachment, were the characteristic features observed in OTA and combination treatments. CIT treatment revealed crenated nucleus, loss of nucleolus, depletion of cytoplasmic organelles, mitochondrial pleomorphism, nuclear fragmentation, uniform folding of cell membrane and cytoplasmic vacuolations in the PCTs. Focal thickening of the glomerular basement membrane and degeneration of endothelial cells were the pr...Continue Reading

References

Sep 1, 1978·Applied and Environmental Microbiology·L K Jackson, A Ciegler
Jan 1, 1976·Toxicon : Official Journal of the International Society on Toxinology·G A SansingM A Miller
Dec 1, 1975·Toxicology and Applied Pharmacology·S SuzukiM Yamazaki
May 1, 1986·Veterinary Pathology·C HanikaJ Tuite
Jul 2, 1974·Biochemistry·H Meisner, S Chan
Sep 1, 1983·Archives of Toxicology·W O Berndt
Dec 1, 1981·Food and Cosmetics Toxicology·N A MehdiJ Tuite
Jan 1, 1994·Natural Toxins·R C BraunbergL Friedman
Jul 11, 2000·Journal of Agricultural and Food Chemistry·T VrabchevaE Märtlbauer
Sep 19, 2003·Archives of Toxicology·József PetrikIvana Cepelak
Sep 3, 2004·Toxicology Letters·G J A Speijers, M H M Speijers
Sep 6, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A H HeussnerE O'Brien
Sep 27, 2005·Toxicology Letters·Feng-Yih YuBiing-Hui Liu
Apr 28, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eva RachedAngela Mally
Sep 1, 2006·Mycopathologia·Paul Bayman, James L Baker

Citations

Apr 24, 2010·Human & Experimental Toxicology·Hassan MalekinejadFereshteh Dardmeh
Apr 3, 2012·Bulletin of Environmental Contamination and Toxicology·Jelka PleadinMate Brstilo
Sep 21, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ting-Shuan WuBiing-Hui Liu
Jul 10, 2012·Toxicology and Industrial Health·Manoj KumarNittin Dev Singh
Dec 14, 2018·Human & Experimental Toxicology·D RašićMaja Peraica
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Dubravka Flajs, Maja Peraica
Oct 12, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chia-Hao ChangBiing-Hui Liu
Apr 19, 2012·Journal of Biochemical and Molecular Toxicology·Zengning LiWeijun Kang
Jan 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Rajeev BhatA A Karim

Related Concepts

Metazoa
Animal Feed (Substance)
Citrinin
Drug Interactions
Kidney
Kidney Tubules, Proximal
Mitochondria
Ochratoxins
Chinchilla Rabbits
Acanthocytes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

© 2021 Meta ULC. All rights reserved