Ocrelizumab after natalizumab in JC-virus positive relapsing remitting multiple sclerosis patients.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Zoë Y G van LieropZle van Kempen

Abstract

Ocrelizumab is often used as an alternative therapy in natalizumab-treated MS patients at risk for progressive multifocal leukoencephalopathy (PML). Our objective was to assess efficacy and safety of JC-virus positive patients switching (either directly or indirectly) from natalizumab to ocrelizumab. Forty-two patients were included from an observational cohort (median follow-up 21 months). No evidence of disease activity was found in 83% of direct switchers and 50% of indirect switchers. Two direct switchers were diagnosed with carry-over PML. Our data support a direct switch for adequate disease suppression, although carry-over PML illustrates the dilemma when choosing between a direct or indirect switch.

References

Apr 27, 2016·Practical Neurology·Gavin GiovannoniKlaus Schmierer
Dec 22, 2016·The New England Journal of Medicine·Stephen L HauserUNKNOWN OPERA I and OPERA II Clinical Investigators
Apr 11, 2020·Neurology. Neuroimmunology and Neuroinflammation·Erik EllwardtStefan Bittner
Oct 9, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Torge RempeTirisham Victoria Gyang
Oct 15, 2020·Neurology. Neuroimmunology and Neuroinflammation·Alyssa A TooropJoep Killestein

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Citations

Sep 5, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hans-Peter HartungThomas Berger

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