Ocrelizumab for treatment of multiple sclerosis

Der Nervenarzt
Jonas GrafHans-Peter Hartung

Abstract

Ocrelizumab is a monoclonal antibody directed against the differentiation antigen CD20, which leads to an effective long-term depletion of lymphocytes, in particular B cells. Recently published phase 3 studies confirmed that ocrelizumab is effective in the treatment of both relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). Based on these results, ocrelizumab was the first drug to be approved for primary chronic progressive MS. To place this therapeutic breakthrough in the context of the current MS therapeutic landscape, it is worthwhile taking a look back at the development of antibody-mediated CD20 depletion, the studies underlying the approval of ocrelizumab and their open extension phases. This review article discusses the available data on the efficacy and safety of long-term B‑cell depletion in MS patients and reviews current knowledge on the role of B‑lymphocytes in the immunopathogenesis of MS.

References

Aug 15, 2006·Journal of Neuroimmunology·Anne H CrossJeri-Anne Lyons
Feb 15, 2008·The New England Journal of Medicine·Stephen L HauserUNKNOWN HERMES Trial Group
Mar 31, 2010·Seminars in Hematology·Stephen A BeersMartin J Glennie
Dec 18, 2012·Journal of Neuropathology and Experimental Neurology·Roberta MagliozziFrancesca Aloisi
May 30, 2014·Neurology·Fred D LublinChris H Polman
Aug 8, 2014·Science Translational Medicine·Arumugam PalanichamyH-Christian von Büdingen
Aug 8, 2014·Science Translational Medicine·Joel N H SternKevin C O'Connor
Oct 4, 2014·European Neurology·Fred D Lublin
Oct 31, 2014·Annals of Clinical and Translational Neurology·Klaus Lehmann-HornMartin S Weber
Dec 11, 2014·Annals of Clinical and Translational Neurology·Daniel C AnthonyDavid Leppert
Mar 10, 2015·Neurology. Neuroimmunology and Neuroinflammation·Anders SvenningssonTommy Bergenheim
Jun 13, 2015·Nature Reviews. Immunology·Ping Shen, Simon Fillatreau
Oct 23, 2015·Science Translational Medicine·Rui LiUNKNOWN Canadian B cells in MS Team
Nov 19, 2015·Frontiers in Immunology·Ana Citlali Márquez, Marc Steven Horwitz
Nov 22, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·P S RommerUNKNOWN GRAID investigators
Jan 29, 2016·Neurology. Neuroimmunology and Neuroinflammation·Margherita NosadiniRussell C Dale
Apr 5, 2016·Annals of Clinical and Translational Neurology·Mika KomoriBibiana Bielekova
Jul 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisabeth SchuhMarkus Krumbholz
Aug 10, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Amandine MathiasRenaud A Du Pasquier
Oct 9, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Judith FraussenVeerle Somers
Nov 1, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ding ChenNancy L Monson
Dec 22, 2016·The New England Journal of Medicine·Peter A Calabresi
Dec 22, 2016·The New England Journal of Medicine·Stephen L HauserUNKNOWN OPERA I and OPERA II Clinical Investigators
Dec 22, 2016·The New England Journal of Medicine·Xavier MontalbanUNKNOWN ORATORIO Clinical Investigators
Feb 9, 2017·Autoimmunity·Hartmut Wekerle
Jun 12, 2017·Journal of Neuroimmunology·Robert P LisakAmit Bar-Or
Jun 27, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Tim SpelmanJan Hillert
Jul 1, 2017·Expert Opinion on Biological Therapy·Dejan JakimovskiRobert Zivadinov
Aug 12, 2017·International Reviews of Immunology·Evangelos A A ChristouFani Ladomenou

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Clinical Trials Mentioned

NCT04032158
NCT02792218
NCT02792231
NCT03277261
NCT03277248
NCT04032171

Software Mentioned

ASCLEPIOS
OLYMPUS
HERMES
ORATORIO

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