Oct-4: more than just a POUerful marker of the mammalian germline?

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
A BrehmHans R Schöler

Abstract

Mammals lack visible cytoplasmic components in the oocyte that could account for 'germline determinants' as identified in various non-mammalian species. Actually, mammals might not define the germline autonomously by localized 'germline determinants' but conditionally depending on the position of cells within the embryo. The Oct-4 gene encodes a transcription factor that is specifically expressed in the toti- and pluripotential stem cells of the mouse embryo and so far has only been found in mammalian species. Oct-4-expressing embryonal cell retain the capacity to differentiate along multiple lineages and they have been suggested to be part of a 'totipotent germline cycle' that links one generation to the next.

References

Dec 15, 1992·Biochemical and Biophysical Research Communications·K OhtaI Matsuda
Mar 29, 1990·Nature·H R SchölerP Gruss
Feb 1, 1992·Molecular and Cellular Biology·R Aurora, W Herr
Feb 1, 1992·Molecular and Cellular Biology·C S HinkleyM Perry
Nov 1, 1991·Mechanisms of Development·Y I YeomK Artzt
Oct 1, 1991·Trends in Genetics : TIG·H R Schöler
Mar 26, 1991·Biochimica Et Biophysica Acta·N Heintz
Jun 1, 1991·Genes & Development·M G Rosenfeld
Mar 1, 1990·Journal of Molecular Graphics·G Vriend
Mar 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I Kemler, W Schaffner
Jul 28, 1989·Biochimica Et Biophysica Acta·M P ScottG W Hartzell

❮ Previous
Next ❯

Citations

May 17, 2000·Molecular Reproduction and Development·D L Kelly, A Rizzino
Sep 24, 2008·Development Genes and Evolution·Young ChaKyung-Soon Park
Jun 5, 2003·Developmental Biology·Kazuyuki OhboToshio Suda
Dec 24, 2008·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xiangqun LiYing Jin
Jan 18, 2006·Nature Cell Biology·Nirit FeldmanYehudit Bergman
Jan 17, 2003·Cell Research·Guang Jin PanDuanqing Pei
Apr 24, 2010·Médecine sciences : M/S·Sonia Stefanovic, Michel Pucéat
May 18, 1999·Current Opinion in Oncology·R T Oliver
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
Apr 27, 2012·PloS One·Ranjeet Singh MahlaSandeep Goel
Nov 30, 2010·Toxicology Letters·Martin BeníšekKlára Hilscherová
Jul 6, 2004·Molecular Reproduction and Development·Monica Bullejos, Peter Koopman
Feb 26, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Henry E YoungAsa C Black
Jun 3, 2004·Cancer Genetics and Cytogenetics·Finn Edler von Eyben
Dec 12, 2003·Cancer Cell·Sharon GidekelEli Pikarsky
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Sandeep GoelHiroshi Imai
Aug 19, 2009·Human Reproduction·Gulcin Abban, Joshua Johnson
Jul 24, 2015·Cell Death & Disease·E A VasilevaN A Barlev
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ho-Joon LeeJonathan L Tilly
Mar 30, 2004·The Journal of Biological Chemistry·Hui Ming XuYing Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

© 2022 Meta ULC. All rights reserved