OCT4: a novel biomarker for dysgerminoma of the ovary

The American Journal of Surgical Pathology
Liang ChengFadi W Abdul Karim

Abstract

The prognosis and therapy for dysgerminomas are different from those of other ovarian tumor types, making accurate diagnosis imperative for patient care. OCT4 (POU5F1) is a transcription factor involved in the regulation of pluripotency during embryonic development. It can be detected in both pluripotent cells and other early germ cells. This study examines the expression of OCT4 in both dysgerminoma and nondysgerminomatous neoplasms involving the ovary. Formalin-fixed, paraffin-embedded cell blocks of 33 cases of dysgerminoma including 2 cases of gonadoblastoma associated with dysgerminoma and 3 cases of metastatic dysgerminoma, and 111 cases of nondysgerminomatous neoplasms involving the ovary were stained using the antibody against OCT4. All cases of dysgerminomas and gonadoblastomas were positive for OCT4 with strong nuclear staining. More than 90% of dysgerminoma cells in each case showed diffuse strong nuclear staining. In addition, 3 metastatic dysgerminomas also showed uniform strong nuclear staining. All nondysgerminomatous tumors (mature teratoma, 14; yolk sac tumor, 4; Sertoli-Leydig cell tumor, 15; granulosa cell tumor, 22; Brenner tumor, 3; carcinoid tumor, 4; struma ovarii, 2; fibroma, 5; thecoma, 1; serous adenoc...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M S Zaghloul, T Y Khattab
Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D WilliamsH D Homesley
Jan 1, 1990·Cancer·E BjörkholmC Silfverswärd
Mar 1, 1988·American Journal of Obstetrics and Gynecology·H H GallionD E Powell
Aug 1, 1982·American Journal of Obstetrics and Gynecology·G De PaloG Rossi
Jan 1, 1995·Human Pathology·B Lifschitz-MercerB Czernobilsky
Jan 1, 1993·Cytogenetics and Cell Genetics·T GuillaudeuxP Pontarotti
Oct 25, 2000·Molecular Human Reproduction·C HansisL C Krey
Feb 13, 2001·Molecular Human Reproduction·C HansisL C Krey
Nov 25, 2003·The American Journal of Pathology·Guangyuan ZengLiang Cheng
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liang ChengJohn N Eble
Jun 26, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alfred S-L ChengJoseph J-Y Sung
Jun 30, 2004·The American Journal of Surgical Pathology·Timothy D JonesLiang Cheng

❮ Previous
Next ❯

Citations

Mar 2, 2005·Nature Reviews. Cancer·J Wolter Oosterhuis, Leendert H J Looijenga
Apr 9, 2005·The Journal of Pathology·Jeroen de JongLeendert H J Looijenga
Feb 24, 2006·Current Opinion in Obstetrics & Gynecology·Eddie F C Murta, Rosekeila S Nomelini
Jun 1, 2006·Endocrine Reviews·Martine CoolsLeendert H J Looijenga
Mar 13, 2008·Genes, Chromosomes & Cancer·Ioannis PanagopoulosFredrik Mertens
Aug 7, 2019·Archives of Pathology & Laboratory Medicine·Si Kei, Oyedele A Adeyi
Nov 23, 2006·The Journal of Pathology·L ChengL H J Looijenga
Mar 4, 2009·Journal of Veterinary Science·Chi-Ho YuJung-Hyang Sur
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Aleksander Talerman, Lawrence M Roth
Sep 23, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lawrence M Roth, Aleksander Talerman
Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Shih-Ming JungPyng-Jing Lin
Nov 23, 2012·Journal of Ovarian Research·Chantel SamardzijaNuzhat Ahmed
Apr 2, 2016·The American Journal of Surgical Pathology·Andrew S WilliamsKelly Dakin Haché
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggage
Apr 7, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Nicole R HowellSharon X Liang
Aug 9, 2006·Current Opinion in Oncology·Daniel M Patterson, Gordon J S Rustin
Dec 20, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Terrence M KatonaLiang Cheng
Aug 20, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Susanna MannistoMarkku Heikinheimo
Apr 20, 2011·Avian Diseases·Anneliese StrunkLisa A Tell
Nov 24, 2006·The American Journal of Surgical Pathology·Sandro SantagataKeith L Ligon
May 26, 2006·The American Journal of Surgical Pathology·Ming-Tse SungLiang Cheng
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paolo Cossu-RoccaLiang Cheng
Apr 28, 2011·Cancer·Liang ChengAntonio Lopez-Beltran
Aug 9, 2007·Journal of Biomedical Science·Chien-Jui ChengYen-Hua Huang
May 7, 2011·Molecules and Cells·Xi ZhouPin Hu
Aug 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael SeverLiang Cheng
May 4, 2006·Advances in Anatomic Pathology·Sean K Lau, Karen L Chang
Nov 26, 2010·The American Journal of Surgical Pathology·Kaoru AbikoIkuo Konishi
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D SatgéM-O Réthoré
Oct 26, 2006·The American Journal of Surgical Pathology·Timothy D JonesLiang Cheng
Aug 14, 2012·Advances in Anatomic Pathology·Saul L Offman, Teri A Longacre
Jan 5, 2019·BMC Cancer·Ezequiel MonferrerRosa Noguera
Apr 7, 2009·Journal of Surgical Oncology·Zhong ChenXue-Jing Xu
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Timothy D JonesLiang Cheng
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ming-Tse SungLiang Cheng
Jun 29, 2011·Bulletin du cancer·Caroline EvenThibault de La Motte Rouge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Lena A KubbaMichael T Deavers
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
T J PelkeyM H Stoler
© 2021 Meta ULC. All rights reserved