Octacalcium phosphate combined with collagen orthotopically enhances bone regeneration

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
S KamakuraO Suzuki

Abstract

Octacalcium phosphate (OCP) is resorbable bone regenerative material, but its brittleness makes it difficult to maintain its shape without restraint. We have engineered a scaffold constructed of synthetic OCP and porcine collagen sponge (OCP/Collagen) and investigated whether OCP/Collagen composite could improve bone regeneration. To examine this hypothesis, bone regeneration by the implantation of OCP/Collagen was compared with those by OCP and collagen. Radiographic and histological examination was performed and the percentage of newly formed bone (n-Bone%) in the defect was determined by a histomorphometrical analysis. OCP/Collagen, OCP, or collagen was implanted into the critical-sized defects in rat crania and fixed at 2, 4, or 8 weeks after implantation. OCP/Collagen improved the handling performance than the granules of OCP, and synergistically enhanced the bone regeneration beyond expectation, which were composed of bone nucleation by OCP and cell infiltration by collagen. Histomorphometrical analysis showed that n-Bone% +/- standard error treated with OCP/Collagen (48.4 +/- 5.14) was significantly higher than those with OCP (27.6 +/- 4.04) or collagen (27.4 +/- 5.69) in week 8. The present study suggests that the combi...Continue Reading

References

May 1, 1991·The Tohoku Journal of Experimental Medicine·O SuzukiM Sakurai
Dec 1, 1987·Advances in Dental Research·W E BrownB Tomazic
Mar 1, 1985·Calcified Tissue International·R Z LeGeros
Mar 1, 1984·Calcified Tissue International·D G Nelson, J D McLean
Nov 1, 1995·Journal of Dental Research·O SuzukiT Aoba
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·P Bodier-HoulléF J Cuisinier
Nov 27, 1999·Journal of Dental Research·S KamakuraK Motegi
May 26, 2001·Zeitschrift für Kardiologie·L AddadiM Geva
Dec 18, 2001·Journal of Biomedical Materials Research·S KamakuraK Motegi
Mar 14, 2002·Biochemical and Biophysical Research Communications·Felicity R A J Rose, Richard O C Oreffo
Apr 9, 2002·Clinical Orthopaedics and Related Research·Racquel Zapanta LeGeros
Jun 26, 2002·Annals of the New York Academy of Sciences·Elliot L ChaikofChristopher M Yip
Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hiroki UedaYasuhiko Shimizu
Aug 20, 2003·Journal of Biomedical Materials Research. Part a·Florence BarrèrePierre Layrolle
Nov 19, 2003·Advanced Drug Delivery Reviews·M GeigerW Friess
Apr 13, 2004·Nature Biotechnology·Catherine M CowanMichael T Longaker
Sep 16, 2004·Journal of Biomedical Materials Research. Part a·S KamakuraY Sasano
Oct 14, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Osamu SuzukiTakenobu Katagiri

❮ Previous
Next ❯

Citations

Sep 29, 2011·Tissue Engineering. Part a·Yuji TanumaOsamu Suzuki
Dec 4, 2013·Tissue Engineering. Part a·Tadashi KawaiShinji Kamakura
Feb 2, 2013·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Aritsune MatsuiSeishi Echigo
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Jun 26, 2012·International Journal of Oral and Maxillofacial Surgery·K MiuraS Echigo
May 18, 2010·Biomaterials·Alvaro MataSamuel I Stupp
Mar 5, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Risa Ishiko-UzukaOsamu Suzuki
Nov 28, 2015·Journal of Tissue Engineering and Regenerative Medicine·Tadashi KawaiShinji Kamakura
May 15, 2009·Clinical Implant Dentistry and Related Research·Tadashi KawaiSeishi Echigo
Jun 8, 2013·Clinical Oral Implants Research·André VajgelNikolaos Donos
Aug 21, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yuji TanumaSeishi Echigo
Nov 2, 2011·Acta Biomaterialia·Shaylin Shadanbaz, George J Dias
Nov 10, 2009·Journal of Dental Research·Y SuzukiO Suzuki
Sep 19, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Fumihiko KajiiShinji Kamakura
Jun 15, 2007·Journal of Biomedical Materials Research. Part a·Shinji KamakuraOsamu Suzuki
Feb 12, 2008·Journal of Tissue Engineering and Regenerative Medicine·Shinji KamakuraOsamu Suzuki
Oct 28, 2011·Tissue Engineering. Part B, Reviews·Caroline SzpalskiStephen M Warren
Aug 1, 2009·Tissue Engineering. Part a·Aritsune MatsuiOsamu Suzuki
Aug 19, 2009·Tissue Engineering. Part C, Methods·Taisuke MasudaOsamu Suzuki
Mar 6, 2019·Journal of Applied Biomaterials & Functional Materials·Hamid TebyanianNafiseh Baheiraei
Nov 14, 2019·Journal of Tissue Engineering and Regenerative Medicine·Atsumu KouketsuShinji Kamakura
Mar 19, 2020·Clinical and Experimental Dental Research·Toshiki YanagisawaShinji Kamakura
Apr 3, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Toshiki YanagisawaShinji Kamakura
Jun 21, 2017·Journal of Tissue Engineering and Regenerative Medicine·Fumihiko KajiiShinji Kamakura
Aug 18, 2020·Tissue Engineering. Part a·Keiko MatsuiShinji Kamakura
Feb 8, 2020·Journal of Tissue Engineering·Tadashi KawaiTetsu Takahashi
Sep 25, 2010·International Journal of Oral and Maxillofacial Surgery·K MatsuiS Echigo
Jul 20, 2021·Tissue Engineering. Part a·Atsumu KouketsuShinji Kamakura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.