Octadecyl ferulate behavior in 1,2-Dioleoylphosphocholine liposomes

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Kervin O EvansSanghoon Kim

Abstract

Octadecyl ferulate was prepared using solid acid catalyst, monitored using Supercritical Fluid Chromatography and purified to a 42% yield. Differential scanning calorimetry measurements determined octadecyl ferulate to have melting/solidification phase transitions at 67 and 39°C, respectively. AFM imaging shows that 5-mol% present in a lipid bilayer induced domains to form. Phase behavior measurements confirmed that octadecyl ferulate increased transition temperature of phospholipids. Fluorescence measurements demonstrated that octadecyl ferulate stabilized liposomes against leakage, maintained antioxidant capacity within liposomes, and oriented such that the feruloyl moiety remained in the hydrophilic region of the bilayer. Molecular modeling calculation indicated that antioxidant activity was mostly influenced by interactions within the bilayer.

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Citations

Nov 20, 2016·Journal of the Science of Food and Agriculture·David L ComptonMichael Appell

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