Octocog alfa, antihaemophilic factor (recombinant), plasma/albumin free method (Advate®): a review of its use in the management of patients with haemophilia A.

Drugs
Sohita Dhillon

Abstract

Octocog alfa, antihaemophilic factor, plasma/albumin free method (Advate®) is a recombinant, human, full-length coagulation factor VIII that does not contain human- or animal-derived plasma proteins. It is indicated for the control and prevention of bleeding episodes, for perioperative management and for routine prophylaxis in children and adults with haemophilia A. This article reviews the pharmacological properties, therapeutic efficacy and tolerability of Advate® in these patients. In previously treated paediatric and adult patients with moderately severe or severe haemophilia A, Advate® administered prophylactically, on demand or during surgery was effective for the prevention and treatment of bleeding episodes in three pivotal, uncontrolled clinical trials. The haemostatic efficacy of Advate® in these trials was rated as 'excellent' or 'good' in most bleeding episodes, with the majority of episodes being managed with one infusion. These findings were supported by pooled analyses of clinical trials and routine clinical practice studies, including the Post-Authorization Safety Study. Additionally, in a comparative study, routine prophylaxis with Advate® administered in a standard regimen or in a pharmacokinetic-tailored regi...Continue Reading

References

Jan 1, 1982·Acta Medica Scandinavica·S A LarssonM Blombäck
Jul 5, 2002·Seminars in Thrombosis and Hemostasis·Jens KlingeEvgueni L Saenko
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Wight, S Paisley
May 25, 2004·Expert Opinion on Pharmacotherapy·Natalya AnanyevaEvgueni Saenko
Sep 11, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·M D TarantinoUNKNOWN RAHF-PFM Clinical Study Group
Jul 27, 2005·British Journal of Haematology·Elena SantagostinoPier Mannuccio Mannucci
Sep 1, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·R PartiL Yang
Feb 16, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·L ScaloneUNKNOWN COCIS Study Investigators
Apr 1, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maximilian FernandezGerald Spotts
Jul 20, 2006·Journal of Thrombosis and Haemostasis : JTH·D M Dimichele, C R M Hay
Feb 9, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Di PaolaR Janco
Sep 22, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·C R M Hay
Aug 10, 2007·The New England Journal of Medicine·Marilyn J Manco-JohnsonBruce L Evatt
May 28, 2008·Journal of Thrombosis and Haemostasis : JTH·V S BlanchetteUNKNOWN rAHF-PFM Clinical Study Group
Jan 16, 2009·Journal of Thrombosis and Haemostasis : JTH·P W CollinsUNKNOWN rAHF-PFM Study Group
Mar 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoC Deguzman
Jun 19, 2009·Therapeutics and Clinical Risk Management·Jerry S Powell
Aug 19, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·I Den UijlK Fischer
Jan 28, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A CoppolaG DI Minno
Jul 9, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·M A Escobar
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·V S Blanchette
Jul 16, 2010·Seminars in Thrombosis and Hemostasis·Massimo Franchini, Giuseppe Lippi
Aug 25, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·P W CollinsUNKNOWN International Prophylaxis Study Group Pharmacokinetics Expert Working Group
Jan 25, 2011·Journal of Thrombosis and Haemostasis : JTH·A GringeriUNKNOWN ESPRIT Study Group
Feb 9, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerB Ewenstein
Feb 16, 2011·Drugs·Trisha Wong, Michael Recht
Aug 6, 2011·Journal of Thrombosis and Thrombolysis·Massimo Franchini, Giuseppe Lippi
Sep 21, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanA Caffarini
Jan 4, 2012·Journal of Thrombosis and Haemostasis : JTH·L A ValentinoUNKNOWN Prophylaxis Study Group
Jan 1, 2010·Journal of Blood Medicine·Antonio CoppolaAnna Maria Cerbone
Feb 9, 2012·Seminars in Thrombosis and Hemostasis·Antonio CoppolaMassimo Franchini

❮ Previous
Next ❯

Citations

Jul 5, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gillian M Keating, Sohita Dhillon
May 27, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·A D ShapiroV Romanov
Feb 11, 2015·Expert Review of Clinical Pharmacology·Peter L TurecekFriedrich Scheiflinger
Aug 2, 2019·The Journal of Pharmacology and Experimental Therapeutics·Helmut GlantschnigWerner Höllriegl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.