PMID: 6406911Jun 23, 1983Paper

Octopamine--a neurohormone with presynaptic activity-dependent effects at crayfish neuromuscular junctions

Nature
C A Breen, H L Atwood

Abstract

Octopamine, the phenol analogue of noradrenaline, is a neurosecretory product found in many vertebrate and invertebrate species. In the American lobster, octopamine produces an increase in muscular tension during activation of the motor nerve and may induce spontaneous contractions at concentrations of 10(-7) M (refs 1,2). In the lobster, postsynaptic mechanisms, including a change in Ca2+ conductance of the muscle membrane, are thought to be responsible for potentiation of contraction. In contrast, studies on insects have implicated both pre- and postsynaptic effects: for example, O'Shea and Evans reported that neuromuscular transmission in the locust leg extensor muscle is modulated by octopamine released from a specific neurosecretory neurone which acts on high-affinity octopamine receptors located both on the muscle and on excitatory nerve terminals. The presynaptic receptors mediate an increase in frequency of spontaneous miniature postsynaptic potentials recorded in the muscle. In view of the apparent discrepancy between insect and crustacean results, we have re-examined the effects of octopamine on neuromuscular transmission in a crustacean muscle and report here that enhanced postsynaptic potentials produced by very low...Continue Reading

References

Mar 1, 1973·The Journal of Physiology·R S Zucker
Sep 1, 1981·The Journal of Physiology·P D Evans

❮ Previous
Next ❯

Citations

Aug 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·B R JohnsonR M Harris-Warrick
Jul 1, 1989·Journal of Neurobiology·G D Bittner
Aug 1, 1997·The European Journal of Neuroscience·R Nargeot, M Moulins
Jul 15, 1996·The Journal of Comparative Neurology·H SchneiderE A Kravitz
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S R Hager, E E Bittar
Oct 27, 1986·Life Sciences·C JacquotJ P Leroy
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·L Fischer, E Florey
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·I M Cooke
Jan 1, 1985·Progress in Neurobiology·J C David, J F Coulon
May 1, 1985·Journal of Neurobiology·I Orchard, A B Lange
Sep 1, 1985·Journal of Neurobiology·A J Mercier, J L Wilkens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.