Octopamine modulates ionic currents and spiking in dorsal unpaired median (DUM) neurons

Neuroreport
H AchenbachD Wicher

Abstract

Modulatory effects of octopamine on ionic currents and spiking in isolated cockroach dorsal unpaired median neurons were investigated by means of the chopped voltage-/current-clamp and the patch-clamp technique. Octopamine increased the spiking frequency at concentrations < or = 10 microM and reduced it at > 10 microM. It enhanced a low voltage-activated Ca2+ current at 1 to 100 microM. At concentrations up to 10 microM two components of Ca2+-activated K+ current were potentiated. At > 10 microM octopamine in addition reduced a high voltage-activated Ca2+ current and the Ca2+-activated K+ current. A membrane permeant cAMP-analogue imitated the effects obtained at high octopamine concentration. Octopamine and cAMP in addition reduced a depolarizing resting current at both low and high concentration. Possible mechanisms and physiological significance are discussed for the opposite effects of octopamine observed at low versus high concentrations.

References

May 1, 1995·Journal of Neurobiology·H Hildebrandt, U Müller
Mar 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·P A Stevenson, U Spörhase-Eichmann
Jan 26, 1996·Neuroscience Letters·J A David, R M Pitman
Jan 1, 1996·Annual Review of Physiology·J T FinnK W Yau

❮ Previous
Next ❯

Citations

Nov 26, 2008·The Journal of Comparative Neurology·Natalia L KononenkoHans-Joachim Pflüger
Nov 1, 2005·Journal of Insect Physiology·M I Zhukovskaya, S V Kapitsky
Jul 16, 2014·Frontiers in Cellular Neuroscience·Marco Canepari
Jun 26, 2009·Journal of Neurophysiology·Heike Demmer, Peter Kloppenburg
Jun 12, 2009·Journal of Neurophysiology·Sandra WestmarkJoachim Schmidt
Oct 9, 2009·Journal of Neurophysiology·Kit D Longden, Holger G Krapp
Dec 2, 2005·The Journal of Biological Chemistry·Dieter WicherChristian Derst
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milena JankowskaMaria Stankiewicz
Dec 7, 2007·The Journal of Experimental Biology·Lior Ann RosenbergFrederic Libersat
Jun 30, 2001·Science·B A TrimmerR M Zayas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.