PMID: 2105376Feb 1, 1990Paper

Octopamine uptake and metabolism in the insect nervous system

Journal of Neurochemistry
J M Wierenga, R M Hollingworth

Abstract

Several insect tissues were examined for their ability to take up octopamine in the presence and absence of sodium ions. The cockroach Malpighian tubules, ovary, and ventral nerve cord showed the highest level of sodium-dependent uptake. The adult firefly lantern exhibited substantial sodium-independent uptake. Some of these tissues were also examined for their ability to metabolize octopamine by N-acetylation. Measurable N-acetyltransferase activity was present in the cockroach ventral nerve cord, tobacco hornworm CNS, and firefly light organ. N-Acetylation is proposed to be the major metabolic pathway for octopamine in the cockroach (Periplaneta americana) nervous system. Several classes of compounds, including octopamine receptor agonists, tricyclic antidepressants, amphetamines, chloroethylbenzylamines, and some experimental insecticides, were tested for their ability to inhibit octopamine uptake and metabolism. The sodium-insensitive component of uptake was not inhibited by most compounds tested, but the sodium-sensitive component was strongly inhibited by xylamine, N-ethyl-N-chloroethyl-o-bromobenzylamine, and their aziridinium ions (60-100%). These compounds also effectively inhibited N-acetyl-transferase (IC50 values at...Continue Reading

References

Jan 1, 1976·International Review of Neurobiology·H A Robertson, A V Juorio
Jan 1, 1977·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·S HayashiE Florey
Apr 1, 1979·Journal of Medicinal Chemistry·R C KammererA K Cho
Apr 1, 1976·Environmental Health Perspectives·R M Hollingworth
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J A ScottC O Knowles
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T F LongL L Murdock
Apr 1, 1987·Journal of Neurochemistry·G L BrookhartL L Murdock
Aug 5, 1985·Life Sciences·H HashemzadehA Voliva
Dec 15, 1972·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S A DewhurstR E McCaman
Jan 1, 1970·European Journal of Pharmacology·F H Leitz, F J Stefano
Dec 1, 1965·Comparative Biochemistry and Physiology·K N Smalley
Aug 1, 1961·The Biochemical Journal·G N WILKINSON

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Citations

Nov 27, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Michael Stern
Nov 27, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·I Yu RauschenbachN E Gruntenko
Sep 30, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·I Yu RauschenbachN E Gruntenko
Jan 1, 1996·Pharmacology & Therapeutics·R H Osborne
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A CapassoE Parisi
Dec 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R Muimo, R E Isaac
Jun 1, 1993·Insect Biochemistry and Molecular Biology·H G Khoo, K P Wong
May 1, 1994·Insect Biochemistry and Molecular Biology·H G Khoo, K P Wong
Jun 1, 1994·Insect Biochemistry and Molecular Biology·C ScavoneJ A Nathanson
Oct 9, 1999·Progress in Neurobiology·T Roeder
Apr 4, 2000·Insect Biochemistry and Molecular Biology·H K LehmanJ G Hildebrand
Jan 24, 2002·Insect Biochemistry and Molecular Biology·Tabita MalutanCam Donly
Nov 10, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E Enan
Feb 13, 2003·European Journal of Biochemistry·Pamela GallantCam Donly
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A NathansonC Scavone
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L DemchyshynH B Niznik
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L CoreyJ Guastella
Dec 11, 2007·Doklady. Biochemistry and Biophysics·N V AdonyevaI Y Rauschenbach
Feb 20, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kevin M CrispXong Yang
Mar 12, 2009·Archives of Insect Biochemistry and Physiology·E V BogomolovaI Yu Rauschenbach
Aug 2, 2013·Journal of Neurophysiology·Kiel G OrmerodJacob L Krans

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