Octreoscan Versus FDG-PET for Neuroendocrine Tumor Staging: A Biological Approach

Annals of Surgical Oncology
Malcolm H SquiresDavid A Kooby

Abstract

Clinicians may order Octreoscan or positron emission tomography (PET) scan for staging patients with neuroendocrine tumors (NETs). (111)In-Octreoscan (Octreoscan) identifies tumors by radiolabeled targeting of somatostatin receptors, while 18F-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) measures differential tissue glucose transport. We assessed the sensitivity of both nuclear imaging modalities with pathologic correlation to define the best initial choice for NET staging after standard cross-sectional imaging. We identified all patients diagnosed with NETs of gastrointestinal or pancreatic origin who underwent nuclear imaging staging by Octreoscan and/or PET from 2000 to 2013. Imaging results were correlated with tumor differentiation and grade of pathology specimens. Imaging and pathology results were identified for 153 patients. Of these, 131 underwent Octreoscan, 43 underwent PET, and 21 patients had both performed. Overall sensitivity of Octreoscan and PET for NET detection was similar (77 vs. 72 %; p = not significant). For well-differentiated NETs, Octreoscan (n = 124) demonstrated sensitivity of 80 vs. 60 % (p = 0.28) for PET (n = 30). For poorly-differentiated NETs, Octreoscan (n = 7) proved significa...Continue Reading

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Citations

Jan 29, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Clément MorgatAntoine Tabarin
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tracey L SmithWadih Arap
Mar 18, 2015·Annals of Surgical Oncology·James R Howe
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Aug 17, 2021·Radiologic Clinics of North America·Samuel J GalganoJ Bart Rose

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