Octreotide Added to a Proton Pump Inhibitor Versus a Proton Pump Inhibitor Alone in Nonvariceal Upper-Gastrointestinal Bleeds

The Annals of Pharmacotherapy
Heidi M RihaMegan A Van Berkel

Abstract

Background: Literature indicating clinically relevant benefits of an adjunctive somatostatin analog to standard therapies in nonvariceal upper-gastrointestinal bleeding (NVUGIB) is lacking. Objective: The primary objective of this study was to find the association between outcomes in patients with NVUGIB treated with octreotide and a proton pump inhibitor (PPI; combination group) compared with those treated with a PPI alone. Methods: We conducted a retrospective cohort study of adults admitted within a 5-hospital health care system with a NVUGIB treated with a PPI continuous infusion with or without an octreotide infusion. Notable exclusion criteria included varices, history of cirrhosis without endoscopy, or active gastrointestinal cancer. The primary outcome was association of combination treatment versus PPI alone with hospital length of stay (LOS). Results: A total of 180 patients were included (combination group: n = 90; PPI: n = 90). In univariate analyses, the median hospital and intensive care unit (ICU) LOS in the combination group versus PPI was 6.1 versus 4.9 days (P = 0.25) and 2.3 versus 1.9 days (P = 0.24), and rebleeding and mortality occurred in 9% versus 12% (P = 0.63) and 6.7% versus 5.6% (P = 1.00) of patient...Continue Reading

References

May 7, 2004·Journal of Clinical Gastroenterology·Vassiliki N NikolopoulouConstantin E Vagianos
Jan 18, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S N SgourosA Avgerinos
Jul 13, 2006·Critical Care : the Official Journal of the Critical Care Forum·Yaseen ArabiMarc Bardou
Mar 24, 2007·The American Journal of Gastroenterology·Panagiotis TsibourisSpyros Potamianos
Jan 20, 2010·Annals of Internal Medicine·Alan N BarkunUNKNOWN International Consensus Upper Gastrointestinal Bleeding Conference Group
Aug 31, 2011·World Journal of Gastroenterology : WJG·Cheol Woong ChoiMong Cho
Oct 15, 2014·Canadian Journal of Gastroenterology & Hepatology·Yidan LuUNKNOWN REASON investigators
Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Erwin Biecker

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