PMID: 8583094Sep 1, 1995Paper

Octreotide and heater probe thermocoagulation for arrest of peptic ulcer hemorrhage. A prospective, randomized, controlled trial

Journal of Clinical Gastroenterology
H J LinS D Lee

Abstract

We carried out a prospective, randomized, controlled trial over a 7-month period to assay the hemostatic effects of octreotide and heater probe thermocoagulation (HPT) in 54 patients with active peptic ulcer bleeding or nonbleeding visible vessels at the ulcer base. Nineteen patients received octreotide 100 micrograms bolus i.v. followed by 25 micrograms/h i.v. for 3 days. Twenty patients received HPT. Fifteen patients received ranitidine 100 mg i.v. every 12 h. The three groups were matched for sex, age, location of bleeders, endoscopic findings, shock, and initial hemoglobin. Ultimate hemostasis was obtained in 11 (58%) of the octreotide group, 18 (90%) of the heater probe group, and 8 (53%) of the control group (p < 0.05). Volume of blood transfused, number of patients receiving operation, hospital stay, and number of deaths were not statistically significant among the three groups. We conclude that HPT is more effective than octreotide in the arrest of peptic ulcer bleeding.

Citations

Nov 7, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Loren Laine, Kenneth R McQuaid
Jul 12, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S N SgourosA Avgerinos
May 7, 2004·Journal of Clinical Gastroenterology·Vassiliki N NikolopoulouConstantin E Vagianos
Jan 16, 2003·The American Journal of Gastroenterology·Brennan M R SpiegelNimish B Vakil
Mar 24, 2007·The American Journal of Gastroenterology·Panagiotis TsibourisSpyros Potamianos
Oct 13, 2004·The Oncologist·Jose Pereira, Tien Phan
Nov 1, 1998·Journal of Gastroenterology and Hepatology·Frank J BranickiJohn Wong

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