PMID: 9537197Apr 16, 1998Paper

Octreotide does not prevent diarrhea in patients treated with weekly 5-fluorouracil plus high-dose leucovorin

American Journal of Clinical Oncology
N J MeropolP J Creaven

Abstract

The somatostatin analog, octreotide, is effective in treating diarrhea associated with cancer chemotherapy. This study was undertaken to determine whether octreotide could be used as prophylaxis against chemotherapy-induced diarrhea and, thereby, permit increased dose intensity. Adult cancer patients were treated with a standard regimen of intravenous 5-fluorouracil (5-FU) (600 mg/m2) plus leucovorin (LV) (500 mg/m2) weekly x 6 weeks. In addition, 150 microg of octreotide was administered subcutaneously twice daily, beginning on the first day of chemotherapy and continuing for 43 days. Escalation of 5-FU was planned for successive cohorts based upon toxicity. Eleven patients were treated at the initial 5-FU dose level. In 10 evaluable patients, dose-limiting toxicities were diarrhea (two patients), fatigue (one patient), and hyperbilirubinemia (one patient). Diarrhea was experienced by six of 10 patients, and only three patients were able to receive six weekly chemotherapy treatments without dose reduction or delay. At a dose of 150 microg twice daily, octreotide did not prevent diarrhea associated with 5-FU plus LV, and 5-FU dose escalation was not possible. While octreotide is successful in the treatment of 5-FU-induced diarr...Continue Reading

References

Sep 1, 1992·Metabolism: Clinical and Experimental·R H DowlingJ A Wass
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S CascinuG Catalano
Nov 21, 1991·The New England Journal of Medicine·H C SoudahC Owyang
Sep 11, 1986·The New England Journal of Medicine·L K KvolsR G Hahn
Oct 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N PetrelliF M Muggia
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J PlessJ Vonderscher
Jun 1, 1986·Clinical Endocrinology·R R DaviesD G Johnston
Sep 1, 1987·The American Journal of Medicine·R J DudlT M O'Dorisio
Jul 1, 1988·Annals of Internal Medicine·R Neta, J J Oppenheim
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·A BrändströmU Junggren
Dec 20, 1995·Journal of the National Cancer Institute·N IkunoM Oka
Jan 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T R BurokerD H Gesme
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S WadlerP H Wiernik
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S CascinuG Catalano

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Citations

Dec 12, 2001·Alimentary Pharmacology & Therapeutics·A Szilagyi, I Shrier
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Sridhar ManiMatthew R Redinbo
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonScott Wadler

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