PMID: 9187545Jan 1, 1996Paper

Octreotide in the control of post-sclerotherapy bleeding from oesophageal varices, ulcers and oesophagitis

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
S A JenkinsR Shields

Abstract

Bleeding from oesophageal varices, oesophageal ulcers or oesophagitis is occasionally massive and difficult to control. Octreotide, a synthetic analogue of somatostin lowers portal pressure and collateral blood flow including that through varices, increases lower oesophageal sphincter pressure, and inhibits the gastric secretion of acid as well as pepsin. Our current experience suggests it is effective in controlling acute variceal haemorrhage. Therefore we have examined the efficacy of octreotide in the control of post-sclerotherapy bleeding from oesophageal varices, oesophageal ulcers and oesophagitis. During the study period 77 patients experienced a significant gastrointestinal bleed (blood pressure < 100 mm Hg, pulse > 100 beats per min or the need to transfuse 2 or more units of blood to restore the hemoglobin level) following injection sclerotherapy of oesophageal varices. The source of bleeding was varices in 42 patients, oesophageal ulcers in 31 and oesophagitis in 4. All patients received a continuous intravenous infusion of octreotide (50 micrograms/h) for between 40-140h. If bleeding was not controlled in the first 12h after commencing octreotide hourly bolus doses (50 micrograms) for 24h were superimposed on the co...Continue Reading

Citations

Jul 7, 2011·World Journal of Hepatology·Michael J Babineaux, Bhupinderjit S Anand
Sep 24, 2013·Orvosi hetilap·László HerszényiZsolt Tulassay
Apr 24, 2003·The Annals of Pharmacotherapy·Sulaiman A Al-Zubairy, Abdulrazaq S Al-Jazairi

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