Octreotide relaxes the hypertensive sphincter of Oddi: pathophysiological and therapeutic implications

The American Journal of Gastroenterology
Ali FazelFrank R Burton

Abstract

As our understanding of the pathophysiology of sphincter of Oddi dysfunction (SOD) expands, new avenues arise for pharmacological intervention. Recent evidence suggests that SOD results from a loss of myenteric plexus inhibitory neurons resulting in unopposed cholinergic tone. Octreotide inhibits postganglionic cholinergic neurons, and thus we hypothesize that administration of octreotide will decrease sphincteric pressure in individuals with SOD. Thirty-eight patients presenting with recurrent abdominal pain and SOD (basal pressure > 40 mm Hg) were studied. The study was prospective, placebo controlled, and blinded. Patient allocation was consecutive. Sphincter of Oddi manometry was performed in standard fashion. The test group (n = 19) received octreotide acetate (100 microg i.v.), and the control group (n = 19) received i.v. saline. Basal, phasic, and duct pressures as well as phasic amplitude and frequency were recorded before and 3 min after the i.v. infusion. Changes in these parameters before and after i.v. infusions were compared. Octreotide caused a statistically significant reduction in peak and basal sphincter of Oddi pressures relative to saline (p < 0.01 and p < 0.001). Octreotide did not significantly affect wave ...Continue Reading

References

Aug 20, 1992·The New England Journal of Medicine·J M VanderwindenM H De Laet
May 1, 1992·Digestive Diseases and Sciences·K F BinmoellerJ P Delmont
Jun 1, 1988·The Journal of Clinical Investigation·J W WileyC Owyang
Nov 1, 1993·European Journal of Clinical Investigation·F MearinJ R Malagelada
Mar 2, 1993·European Journal of Pharmacology·J G PauletzkiE A Shaffer
Apr 25, 1996·The New England Journal of Medicine·R K Goyal, I Hirano
Apr 1, 1997·The American Journal of Gastroenterology·S Waldstreicher
Jun 1, 1997·Digestive Diseases and Sciences·F H WeberP Yeaton
Mar 24, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A MaselliD Lorusso
Jun 1, 1995·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A BonhommeM Bernard

❮ Previous
Next ❯

Citations

Apr 25, 2012·World Journal of Gastroenterology : WJG·Véronique VittonMarc Barthet
Jan 1, 2008·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Prasad Seetharam, Gabriel Rodrigues
Jun 6, 2003·Pharmacology & Toxicology·Mark Berner Hansen
Aug 9, 2011·The Journal of International Medical Research·M Skalicky
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Onesmo B BalembaGary M Mawe
Jun 12, 2004·Current Gastroenterology Reports·Kinnari Kher, Moises Guelrud
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·F BurtonUNKNOWN North American Pancreatic Study Group
Aug 31, 2019·Digestive Diseases and Sciences·Juhyeun KimAbraham Hartzema
Jun 29, 2006·World Journal of Gastroenterology : WJG·Lana Bistritz, Vincent G Bain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.