Ocular adnexal diffuse large B-cell lymphoma: local disease correlates with better outcomes

Eye
S N MadgeD Selva

Abstract

To describe the clinical, immunohistochemical and prognostic features, as well as outcomes of a large series of patients with orbital and periorbital diffuse large B-cell lymphoma (DLBCL). This study is a multicentre, retrospective non-comparative consecutive case series. The setting for this study was institutional. A total of 37 consecutive patients identified from the institutions' databases with periorbital and orbital DLBCL were enrolled in the study. A retrospective chart review was used for observation. The main outcome measures were patient demographics, clinical features, imaging, immunohistochemical and histopathological data, treatments administered, and survival. A total of 20 out of 37 cases (54.1%) represented localised periorbital disease (group L), 11 of 37 (29.7%) had systemic disease at presentation with periorbital disease (group S1), and 6 of 37 (16.2%) had previous history of systemic lymphoma (group S2). In all, 28 out of 30 (93.3%) patients were CD20+, 5 of 25 (20%) were CD3+, and 11 of 11 (100%) were CD79a+ (varying denominators reflect the different numbers of patients tested). A total of 25 out of 32 patients (78.1%) received chemotherapy, 14 (43.8%) received rituxmab plus chemotherapy, and 19 (59.3%) ...Continue Reading

References

Nov 1, 1988·Ophthalmic Surgery·D S RootmanH E Kaufman
Mar 10, 1999·Acta Ophthalmologica Scandinavica·S Seregard, S Sahlin
Jan 10, 2002·Clinical & Experimental Ophthalmology·P A McKelvieJ O'Day
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Feb 5, 2002·Ophthalmology·Hakan DemirciJose C Tovilla
Jul 27, 2002·Ophthalmic Plastic and Reconstructive Surgery·Bita EsmaeliLawrence Ginsberg
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Sylvie MartinetRené Olivier Mirimanoff
Nov 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard W TsangBruce J Patterson
Apr 15, 2004·Ophthalmic Plastic and Reconstructive Surgery·Timothy J SullivanIan Bunce
Jan 5, 2005·Ophthalmology·Audrey LooiValerie A White
Mar 15, 2005·Ophthalmology Clinics of North America·David S Bardenstein
Jun 9, 2005·Ophthalmic Plastic and Reconstructive Surgery·Timothy J SullivanGraeme Dickie
Oct 21, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K TanimotoK Tobinai
Feb 16, 2006·The American Journal of the Medical Sciences·Shahid AhmedBhoomi Mehrotra
Oct 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Niklaus G SchaeferThomas F Hany
Aug 19, 2007·Current Opinion in Ophthalmology·Francesco P Bernardini, Mario Bazzan
Jan 10, 2008·Archives of Pathology & Laboratory Medicine·Kristin E Hunt, Kaaren K Reichard
Oct 1, 1987·Indian Journal of Psychiatry·S M Channabasavanna

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Citations

Jan 1, 2010·Digital Journal of Ophthalmology : DJO·Timothy S SaundersMyron Yanoff
Jun 11, 2011·Ophthalmic Plastic and Reconstructive Surgery·Daniel B RootmanJack Rootman
Apr 17, 2012·American Journal of Ophthalmology·Rebecca C StacyHans E Grossniklaus
May 4, 2012·Acta Ophthalmologica·Peter K RasmussenSteffen Heegaard
Apr 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hind M AlkatanAyman Al-Ayoubi
Apr 4, 2014·The Lancet Oncology·Andrés J M Ferreri
Nov 13, 2015·Ophthalmic Plastic and Reconstructive Surgery·Frederick A JakobiecDaniel R Lefebvre
Feb 8, 2019·The Journal of Craniofacial Surgery·Tushar SarbajnaHirohiko Kakizaki
Mar 9, 2018·International Ophthalmology Clinics·Leslie NeemsPrem S Subramanian
Jul 17, 2021·The Journal of Craniofacial Surgery·Jonghyun KimSehyun Baek

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