Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Aleksandra PetrovicMehrad Hamedani

Abstract

To report the clinico-pathological features of solitary fibrous tumor occurring in the ocular adnexa (OA) in a single center. To assess the presence of NAB2-STAT6 genes fusion in OA solitary fibrous tumor detected by nuclear overexpression of STAT6. Retrospective study including orbital and OA solitary fibrous tumors treated between 2006 and 2014 in our center. The clinical, radiological, and histopathological findings were evaluated. STAT6 expression was assessed by immunohistochemistry. Five patients were identified and presented with a chronic OA mass. The tumors were radiologically well delimited, highly vascularized and without bone erosion. All the patients underwent complete surgical excision. Pathological examination confirmed solitary fibrous tumor in all cases. All tumors demonstrated a nuclear expression of STAT6. There were no recurrences, with a mean follow-up of 5 years after surgery. Our review demonstrated that proptosis was the most common presentation occurring in 60 % of the cases. In the ocular adnexa, adverse histological criteria were found in 19.7 % of the tumors, and recurrences were observed in 48 % of these cases. Thirty-six percent of patients presented at least one local recurrence, and metastastic s...Continue Reading

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Citations

Jul 14, 2016·Journal of Maxillofacial and Oral Surgery·Arvind KrishnamurthyArvind Krishnamurthy
Dec 27, 2019·Ophthalmic Plastic and Reconstructive Surgery·Nathan W BlessingThomas E Johnson
Jan 1, 2020·BMC Urology·Tsung-Hsin ChangChih-Chiao Lee
Jun 5, 2020·Ophthalmic Plastic and Reconstructive Surgery·Chad H JacksonGerald J Harris

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