PMID: 4064737Sep 1, 1985

Ocular aminopeptidase activity and distribution in the albino rabbit

Current Eye Research
R E Stratford, V H Lee

Abstract

Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the iris-ciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.

References

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Citations

Jan 1, 1986·Journal of Ocular Pharmacology·V H Lee, J R Robinson
Dec 28, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T L KeR W Gracy
Mar 22, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Najam A SharifAta A Abdel-Latif
Mar 24, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Robert FaulknerDavid Dahlin
Jan 1, 1988·Journal of Ocular Pharmacology·G C Chiou, C Y Chuang
Jan 1, 1989·Journal of Ocular Pharmacology·G C ChiouM S Chang
Sep 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S E CouplandF A Billson
Nov 22, 2005·Expert Opinion on Drug Delivery·Mayssa AttarDiane Tang-Liu
Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kishore CholkarAshim K Mitra
May 1, 1986·Current Eye Research·K K Sharma, B J Ortwerth
Apr 26, 2017·Drug Metabolism Reviews·Upendra A ArgikarAndrea J Bushee

Related Concepts

Aminopeptidase
Ciliary Body
Structure of Bulbar Conjunctiva
Cornea
Corneal Stroma
Mesothelium
Eye
Iris (Eye)
Tears Body Substance
Drug or Chemical Tissue Distribution

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