PMID: 8606034Feb 1, 1996Paper

Ocular and dermal irritation studies of some quaternary ammonium compounds

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
G H Lin, M Hemming

Abstract

The primary ocular and dermal irritations of four quaternary ammonium compounds, namely cetylpyridinium chloride (CPC), stearylphenylethyldimethylammonium tosylate (SPDAT), dimethyldistearylammonium bisulfate (DDABS) and tri(N-butyl)benzylammonium 4-hydroxynapththalene-1-sulfonate (TBAHNS), were studied. Both CPC and SPDAT were extremely or severely irritating to the eyes of the test animals, whereas DDABS and TBAHNS were mildly or minimally irritating. Both CPC and SPDAT were also severely or extremely irritating to the skin of the test animals, while DDABS and TBAHNS were non-irritating. These quaternary ammonium compounds have little similarity in chemical structure and possess different solubilities. CPC is very soluble in both lipid and water; SPDAT is very soluble in lipid but only slightly soluble in water; and DDABS and TBAHNS are poorly soluble in either lipid or water. The irritancy of these compounds is likely to be related to their solubility, in addition to the cationic characteristics. It appears that not all quaternary ammonium compounds in this study are irritants. Those that are not soluble are not expected to be absorbed in eye/skin tissues and thus irritation reactions will not take place. The use of in vitro...Continue Reading

References

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Citations

Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pascal FurrerRobert Gurny
May 11, 2010·Pediatric Emergency Care·Mathew GeorgeAlan D Woolf
Jul 8, 2008·Regulatory Toxicology and Pharmacology : RTP·Montserrat MitjansM Pilar Vinardell
Aug 16, 2005·Regulatory Toxicology and Pharmacology : RTP·Harrie E BuistCees de Heer
Oct 20, 2007·Letters in Applied Microbiology·A Houari, P Di Martino
Mar 7, 2013·International Journal of Pharmaceutics·Majella E Lane
Dec 9, 2014·Reproductive Toxicology·Vanessa E MelinTerry C Hrubec
Dec 24, 2014·Pharmaceutics·Meera Gujjar, Ajay K Banga
Mar 21, 2015·Jundishapur Journal of Microbiology·Azizollah EbrahimiShahin Khubani
Feb 6, 2016·Materials·Sandra MaginaDmitry Evtuguin

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